Details of Metabolite

General Information of MET (ID: META00935)
Name Tectorigenin
Synonyms   Click to Show/Hide Synonyms of This Metabolite
5,7,4'-Trihydroxy-6-methoxyisoflavone, 4',5',7-Trihydroxy-6-methoxyisoflavone
Source Endogenous;Drug;Polyketides;Food;TCM Ingredients;kakkalide;Plant Metabolite; Herbal Ingredients In-Vivo Metabolism
Structure Type   Isoflav-2-enes  (Click to Show/Hide the Complete Structure Type Hierarchy)
Phenylpropanoids and polyketides
Isoflavonoids
Isoflav-2-enes
PubChem CID
5281811
HMDB ID
HMDB0042024
Formula
C16H12O6
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C10534
ChEBI ID
9429
FooDB ID
FDB029978
ChemSpider ID
4445122
Physicochemical Properties Molecular Weight 300.26 Topological Polar Surface Area 96.2
XlogP 2.6 Complexity 454
Heavy Atom Count 22 Rotatable Bond Count 2
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 6
Function
Tectorigenin is an O-methylated isoflavone, a type of flavonoid. It can be isolated from leopard lily (Belamcanda chinensis) or Pueraria thunbergiana.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transcription factor (TF)
            R2R3-MYB (AN2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of AN2
                      Induced Change Tectorigenin concentration: increase (FC = 2.18)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of AN2 leads to the increase of tectorigenin levels compared with control group.
References
1 Comprehensive Influences of Overexpression of a MYB Transcriptor Regulating Anthocyanin Biosynthesis on Transcriptome and Metabolome of Tobacco Leaves. Int J Mol Sci. 2019 Oct 16;20(20):5123.

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