Details of Metabolite

General Information of MET (ID: META00929)
Name 5,7-Dihydroxy-3',4',5'-trimethoxyflavone
Synonyms   Click to Show/Hide Synonyms of This Metabolite
5,7-Dihydroxy-2-(3,4,5-trimethoxyphenyl)-4-benzopyrone; 5,7-Dihydroxy-2-(3,4,5-trimethoxyphenyl)-4H-1-benzopyran-4-one; 5,7-Dihydroxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one', Tricetin 3',4',5'-trimethyl ether, 5, 7-Dihydroxy-3',4',5'-trimethoxyflavone, 5,7-Dihydroxy-3',4',5'-trimethoxy flavone, 5,7-Dihydroxy-3',4',5'-trimethoxy-flavone, 5,7-Dihydroxy-3',4',5'-trimethoxyflavon, 'Dimethyl benzoylphosphonate', Flavone, 5,7-dihydroxy-3',4',5'-trimethoxy- (8ci), 5,7-Dihydroxy-3',4',5'-trimethoxyflavone
Source Food;Polyketides;Food;TCM Ingredients
Structure Type   O-methylated flavonoids  (Click to Show/Hide the Complete Structure Type Hierarchy)
Phenylpropanoids and polyketides
Flavonoids
O-methylated flavonoids
PubChem CID
5379265
HMDB ID
HMDB0037692
Formula
C18H16O7
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C19807
ChEBI ID
543745
FooDB ID
FDB016820
ChemSpider ID
4527900
Physicochemical Properties Molecular Weight 344.3 Topological Polar Surface Area 94.4
XlogP 2 Complexity 506
Heavy Atom Count 25 Rotatable Bond Count 4
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 7
Function
5,7-Dihydroxy-3',4',5'-trimethoxyflavone is found in cereals and cereal products. 5,7-Dihydroxy-3',4',5'-trimethoxyflavone is isolated from leaves of barley (Hordeum vulgare).
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transcription factor (TF)
            R2R3-MYB (AN2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of AN2
                      Induced Change 5,7-Dihydroxy-3',4',5'-trimethoxyflavone concentration: increase (FC = 2.37)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of AN2 leads to the increase of 5,7-dihydroxy-3',4',5'-trimethoxyflavone levels compared with control group.
References
1 Comprehensive Influences of Overexpression of a MYB Transcriptor Regulating Anthocyanin Biosynthesis on Transcriptome and Metabolome of Tobacco Leaves. Int J Mol Sci. 2019 Oct 16;20(20):5123.

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