Details of Metabolite

General Information of MET (ID: META00927)
Name Cosmosiin
Synonyms   Click to Show/Hide Synonyms of This Metabolite
5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside; 7-(beta-D-Glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one', 7-O-beta-D-Glucosyl-5,7,4'-trihydroxyflavone, 'Apigenin 7-O-glucoside; Apigenin 7-O-b-D-glucoside; Apigenin 7-O-beta-D-glucopyranoside; Apigenin 7-O-beta-D-glucoside; Apigenin 7-O-beta-glucopyranoside; Apigenin 7-beta-D-glucoside; Apigenin 7-beta-glucopyranoside; Apigenin 7-glucoside; Apigenin-7-D-glucoside; Apigenin-7-O-beta-D-glucopyranoside; Apigenin-7-glucoside; Apigetrin; Cosmetin; Cosmociin; Cosmoside; Cosmosiin; Cosmosiine; Cosmosioside
Source Food
Structure Type   Flavonoid glycosides  (Click to Show/Hide the Complete Structure Type Hierarchy)
Phenylpropanoids and polyketides
Flavonoids
Flavonoid glycosides
PubChem CID
5280704
HMDB ID
HMDB0037340
Formula
C21H20O10
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C04608
ChEBI ID
16778
FooDB ID
FDB016362
ChemSpider ID
4532607
Physicochemical Properties Molecular Weight 432.4 Topological Polar Surface Area 166
XlogP -0.1 Complexity 675
Heavy Atom Count 31 Rotatable Bond Count 4
Hydrogen Bond Donor Count 6 Hydrogen Bond Acceptor Count 10
Function
Cosmosiin, also known as apigenin 7-O-glucoside or apigetrin, is a member of the class of compounds known as flavonoid-7-O-glycosides. Flavonoid-7-O-glycosides are phenolic compounds containing a flavonoid moiety which is O-glycosidically linked to carbohydrate moiety at the C7-position. Cosmosiin is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Cosmosiin can be found in a number of food items, such as common thyme, white lupine, common oregano, and orange mint. Cosmosiin can also be found in dandelion coffee and in Teucrium gnaphalodes. Cosmosiin can also be found plants such as wild celery and anise. Cosmosiin has been shown to exhibit anti-platelet function.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transcription factor (TF)
            R2R3-MYB (AN2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of AN2
                      Induced Change Cosmosiin concentration: decrease (FC = 0.48)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of AN2 leads to the decrease of cosmosiin levels compared with control group.
References
1 Comprehensive Influences of Overexpression of a MYB Transcriptor Regulating Anthocyanin Biosynthesis on Transcriptome and Metabolome of Tobacco Leaves. Int J Mol Sci. 2019 Oct 16;20(20):5123.

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