Details of Metabolite

General Information of MET (ID: META00925)
Name Phlorizin
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Floridzin', Phloretin 2'-glucoside, 'Phlorhizin; Phloridzin; Phloridzosid; Phlorizine; Phlorizoside', Phloretin-2'-beta-glucoside, Phloretin-2'-O-beta-glucoside, 'Phloridzinum; Phlorrhizen; Phlorrhizin
Source Drug;Food;Cosmetic;TCM Ingredients;Plant Metabolite
Structure Type   Flavonoid glycosides  (Click to Show/Hide the Complete Structure Type Hierarchy)
Phenylpropanoids and polyketides
Flavonoids
Flavonoid glycosides
PubChem CID
6072
HMDB ID
HMDB0036634
Formula
C21H24O10
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C01604
ChEBI ID
8113
FooDB ID
FDB015554
ChemSpider ID
16498836
Physicochemical Properties Molecular Weight 436.4 Topological Polar Surface Area 177
XlogP 1.2 Complexity 581
Heavy Atom Count 31 Rotatable Bond Count 7
Hydrogen Bond Donor Count 7 Hydrogen Bond Acceptor Count 10
Function
Phlorizin is found in apple. Phlorizin is isolated from apple leaves and bark.Phlorizin is a toxic glycoside made by some plants. It belongs to the group of flavonoids. It is a competitive inhibitor of renal glucose transport.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transcription factor (TF)
            R2R3-MYB (AN2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of AN2
                      Induced Change Phlorizin concentration: increase (FC = 12.16)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of AN2 leads to the increase of phlorizin levels compared with control group.
References
1 Comprehensive Influences of Overexpression of a MYB Transcriptor Regulating Anthocyanin Biosynthesis on Transcriptome and Metabolome of Tobacco Leaves. Int J Mol Sci. 2019 Oct 16;20(20):5123.

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