Details of Metabolite

General Information of MET (ID: META00912)
Name (-)-Epiafzelechin
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(2R,3R)-Epiafzelechin; Epi-afzelechin; Epiafzelechin
Source Endogenous;Polyketides;Food
Structure Type   Flavans  (Click to Show/Hide the Complete Structure Type Hierarchy)
Phenylpropanoids and polyketides
Flavonoids
Flavans
PubChem CID
443639
HMDB ID
HMDB0030822
Formula
C15H14O5
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C12128
ChEBI ID
31028
FooDB ID
FDB002778
Physicochemical Properties Molecular Weight 274.27 Topological Polar Surface Area 90.2
XlogP 0.7 Complexity 328
Heavy Atom Count 20 Rotatable Bond Count 1
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 5
Function
(-)-Epiafzelechin is found in fruits. (-)-Epiafzelechin is a constituent of Actinidia chinensis (kiwi fruit) and Juniperus communis (juniper)
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transcription factor (TF)
            R2R3-MYB (AN2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of AN2
                      Induced Change (-)-Epiafzelechin concentration: increase (FC = 5.27)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of AN2 leads to the increase of (-)-epiafzelechin levels compared with control group.
References
1 Comprehensive Influences of Overexpression of a MYB Transcriptor Regulating Anthocyanin Biosynthesis on Transcriptome and Metabolome of Tobacco Leaves. Int J Mol Sci. 2019 Oct 16;20(20):5123.

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