Details of Metabolite

General Information of MET (ID: META00910)
Name Desmethylxanthohumol
Synonyms   Click to Show/Hide Synonyms of This Metabolite
1-(2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-butenyl)phenyl)-3-(4-hydroxyphenyl)-2-propen-1-one; 3-(4-Hydroxyphenyl)-1-[2,4,6-trihydroxy-3-(3-methyl-2-butenyl)phenyl]-2-propen-1-one; Xanthohumol
Source Endogenous;Food
Structure Type   Chalcones and dihydrochalcones  (Click to Show/Hide the Complete Structure Type Hierarchy)
Phenylpropanoids and polyketides
Linear 1,3-diarylpropanoids
Chalcones and dihydrochalcones
PubChem CID
6443339
HMDB ID
HMDB0030610
Formula
C20H20O5
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C16416
ChEBI ID
80489
FooDB ID
FDB002506
ChemSpider ID
4947362
Physicochemical Properties Molecular Weight 340.4 Topological Polar Surface Area 98
XlogP 4.7 Complexity 500
Heavy Atom Count 25 Rotatable Bond Count 5
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 5
Function
Desmethylxanthohumol is found in alcoholic beverages. Desmethylxanthohumol is a constituent of Humulus lupulus (hops)
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transcription factor (TF)
            R2R3-MYB (AN2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of AN2
                      Induced Change Desmethylxanthohumol concentration: decrease (FC = 0.33)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of AN2 leads to the decrease of desmethylxanthohumol levels compared with control group.
References
1 Comprehensive Influences of Overexpression of a MYB Transcriptor Regulating Anthocyanin Biosynthesis on Transcriptome and Metabolome of Tobacco Leaves. Int J Mol Sci. 2019 Oct 16;20(20):5123.

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