Details of Metabolite

General Information of MET (ID: META00907)
Name Chalconaringenin
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2',4',6',4-Tetrahydroxychalcone, 2'4'6'4-Tetrahydroxychalcone, 'Isosalipurpol; Naringenin chalcone', 2',4,4',6'-Tetrahydroxychalcone, '3-(4-Hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-2-propen-1-one, 9ci; Naringenin chalcone, (e)-isomer
Source Endogenous;Drug;Polyketides;Food;Plant Metabolite
Structure Type   Chalcones and dihydrochalcones  (Click to Show/Hide the Complete Structure Type Hierarchy)
Phenylpropanoids and polyketides
Linear 1,3-diarylpropanoids
Chalcones and dihydrochalcones
PubChem CID
5280960
HMDB ID
HMDB0029631
Formula
C15H12O5
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C06561
ChEBI ID
15413
FooDB ID
FDB000801
ChemSpider ID
4444447
Physicochemical Properties Molecular Weight 272.25 Topological Polar Surface Area 98
XlogP 2.8 Complexity 347
Heavy Atom Count 20 Rotatable Bond Count 3
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 5
Function
Chalconaringenin is found in garden tomato. Chalconaringenin is isolated from tomato fruit cuticle
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transcription factor (TF)
            R2R3-MYB (AN2) Click to Show/Hide the Full List of Regulating Pair(s):   2 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair (1) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of AN2
                      Induced Change Chalconaringenin concentration: increase (FC = 9.25)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of AN2 leads to the increase of chalconaringenin levels compared with control group.
               Regulating Pair (2) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of AN2
                      Induced Change Chalconaringenin concentration: increase (FC = 2.33)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of AN2 leads to the increase of chalconaringenin levels compared with control group.
References
1 Comprehensive Influences of Overexpression of a MYB Transcriptor Regulating Anthocyanin Biosynthesis on Transcriptome and Metabolome of Tobacco Leaves. Int J Mol Sci. 2019 Oct 16;20(20):5123.

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