Details of Metabolite

General Information of MET (ID: META00848)
Name Benzamide
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Amid kyseliny benzoove; Benzamide (acd/name 4.0); Benzenecarboxamide; Benzoate; Benzoate amide; Benzoic acid; Benzoic acid amide; Benzoylamide; PHC(=O)NH2; PHC(O)NH2; Phenyl carboxyamide; Phenylcarboxamide; Phenylcarboxyamide; Tigan; Trimethobenzamide hydrochloride
Source Endogenous;Food
Structure Type   Benzoic acids and derivatives  (Click to Show/Hide the Complete Structure Type Hierarchy)
Benzenoids
Benzene and substituted derivatives
Benzoic acids and derivatives
PubChem CID
2331
HMDB ID
HMDB0004461
Formula
C7H7NO
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C09815
ChEBI ID
28179
FooDB ID
FDB023373
ChemSpider ID
2241
Physicochemical Properties Molecular Weight 121.14 Topological Polar Surface Area 43.1
XlogP 0.6 Complexity 106
Heavy Atom Count 9 Rotatable Bond Count 1
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 1
Function
Benzamide is an intermediate in the Benzoate degradation via CoA ligation. Benzamides are a class of chemical compounds derived from Benzamid, the carbonic acid amide of benzoic acid. In psychiatry some substituted benzamides are therapeutically used as neuroleptics and/or antipsychotics.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transcription factor (TF)
            R2R3-MYB (AN2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of AN2
                      Induced Change Benzamide concentration: decrease (FC = 0.48)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of AN2 leads to the decrease of benzamide levels compared with control group.
References
1 Comprehensive Influences of Overexpression of a MYB Transcriptor Regulating Anthocyanin Biosynthesis on Transcriptome and Metabolome of Tobacco Leaves. Int J Mol Sci. 2019 Oct 16;20(20):5123.

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