Details of Metabolite

General Information of MET (ID: META00827)
Name 4-Methoxycinnamic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(2E)-3-(4-Methoxyphenyl)-2-propenoic acid; (2E)-3-(4-Methoxyphenyl)prop-2-enoate; (e)-3-(4-Methoxyphenyl)-2-propenoic acid; (e)-3-(4-Methoxyphenyl)acrylate; (e)-3-(4-Methoxyphenyl)acrylic acid; (e)-4-Methoxycinnamic acid; (e)-p-Methoxycinnamic acid; 3-(4-Methoxy-phenyl)-acrylate; 3-(4-Methoxy-phenyl)-acrylic acid; 3-(4-Methoxyphenyl)-2-propenoate; 3-(4-Methoxyphenyl)-2-propenoic acid; 3-(4-Methoxyphenyl)acrylate; 3-(4-Methoxyphenyl)acrylic acid; 4-Methoxy cinnamate; 4-Methoxy cinnamic acid; 4-Methoxycinnamate; 4-Methoxycinnamate, (Z)-isomer; 4-Methoxycinnamate, (e)-isomer; 4-Methoxycinnamate, aluminum salt; 4-Methoxycinnamate, calcium salt; 4-Methoxycinnamate, magnesium salt; 4-Methoxycinnamate, potassium salt; 4-Methoxycinnamate, sodium salt; 4-Methoxycinnamate, zinc salt; 4-Methoxycinnamate, zirconium salt; 4-Methoxycinnamic acid; O-Methyl-p-coumarate; O-Methyl-p-coumaric acid; Para-methoxycinnamate; Para-methoxycinnamic acid; e-p-Methoxycinnamic acid; p-Hydroxy methyl cinnamate; p-Methoxy ciannamate; p-Methoxy ciannamic acid; p-Methoxycinnamate; p-Methoxycinnamic acid; trans-3-(4-Methoxyphenyl)-2-propenoic acid; trans-4-Methoxycinnamate; trans-4-Methoxycinnamic acid; trans-p-Methoxycinnamate; trans-p-Methoxycinnamic acid
Source Endogenous;Food;TCM Ingredients
Structure Type   Cinnamic acids  (Click to Show/Hide the Complete Structure Type Hierarchy)
Phenylpropanoids and polyketides
Cinnamic acids and derivatives
Cinnamic acids
PubChem CID
699414
HMDB ID
HMDB0002040
Formula
C10H10O3
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
260249
FooDB ID
FDB002667
ChemSpider ID
609479
METLIN ID
6453
Physicochemical Properties Molecular Weight 178.18 Topological Polar Surface Area 46.5
XlogP 1.8 Complexity 190
Heavy Atom Count 13 Rotatable Bond Count 3
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3
Function
4-Methoxycinnamic acid (CAS: 830-09-1), also known as p-methoxycinnamic acid, is a methoxy derivative of cinnamic acid. Esters of 4-methoxycinnamic acid are among the popular UV-B screening compounds used in various cosmetic formulations in sunscreen products.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transcription factor (TF)
            R2R3-MYB (AN2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of AN2
                      Induced Change 4-Methoxycinnamic acid concentration: increase (FC = 4.05)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of AN2 leads to the increase of 4-methoxycinnamic acid levels compared with control group.
References
1 Comprehensive Influences of Overexpression of a MYB Transcriptor Regulating Anthocyanin Biosynthesis on Transcriptome and Metabolome of Tobacco Leaves. Int J Mol Sci. 2019 Oct 16;20(20):5123.

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