General Information of MET (ID: META00822)
Name Aminocaproic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
6 Aminocaproic acid; 6 Aminohexanoic acid; 6-Amino-N-hexanoate; 6-Amino-N-hexanoic acid; 6-Amino-hexanoate; 6-Amino-hexanoic acid; 6-Aminocaproate; 6-Aminocaproic acid; 6-Aminohexanoate; 6-Aminohexanoic acid; AMINOCAPROIC; Acepramin; Acepramine; Acide aminocaproque; Acido aminocaproico; Acidum aminocaproicum; Acikaprin; Afibrin; Ahx; Amicar; Amikar; Aminocaproate; Aminohexanoate; Aminohexanoic acid; Aminokapron; Atsemin; Caplamin; Capracid; Capralense; Capramol; Capranol; Caproamin; Caprocid; Caprolest; Caprolisin; Delagrange brand OF aminocaproic acid; EACA; Epsamon; Epsicaprom; Epsicapron; Epsikapron; Epsilcapramin; Epsilcapramine; Epsillon-aminocaproate; Epsillon-aminocaproic acid', Epsillon-aminocaproic acid' epsilcapramin, 'epsilon-Aminocaproic acid usp; Epsilon S; H-6-Ahx-OH; H-EAhx-OH; H-epsilon-Acp-OH; Hemocaprol; Hemopar; Hepin; Hexalense; Ipsilon; Leurquin brand OF aminocaproic acid; Omega-aminocaproate; Omega-aminocaproic acid; Omega-aminohexanoate; Omega-aminohexanoic acid; Pharmachemie brand OF aminocaproic acid; Respramin; Rottapharm brand OF aminocaproic acid; Sanofi winthrop brand OF aminocaproic acid; W-Aminocaproate; W-Aminocaproic acid; W-Aminohexanoate; W-Aminohexanoic acid; Z; e-Amino-N-hexanoate; e-Amino-N-hexanoic acid; e-Aminocaproate; e-Aminocaproic acid; e-Aminocaproic acid usp; e-Aminohexanoate; e-Aminohexanoic acid; e-Leucine; e-Norleucine; epsilon Aminocaproic acid; epsilon-Ahx; epsilon-Amino-N-hexanoate; epsilon-Amino-N-hexanoic acid; epsilon-Aminocaproate; epsilon-Aminocaproic acid; epsilon-Aminohexanoate; epsilon-Aminohexanoic acid; epsilon-Leucine; epsilon-Norleucine; epsilon-S
Source Fatty acyls;Food;Carcinogenic Potency;Drug;Cosmetic
Structure Type   Fatty acids and conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Fatty acids and conjugates
PubChem CID
564
HMDB ID
HMDB0001901
Formula
C6H13NO2
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C02378
DrugBank ID
DB00513
ChEBI ID
16586
FooDB ID
FDB022729
ChemSpider ID
548
Physicochemical Properties Molecular Weight 131.17 Topological Polar Surface Area 63.3
XlogP -3 Complexity 83.1
Heavy Atom Count 9 Rotatable Bond Count 5
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Function
Aminocaproic acid (marketed as Amicar) is a drug used to treat bleeding disorders. It is an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties. It is a derivative of the amino acid lysine. It binds reversibly to the kringle domain of plasminogen and blocks the binding of plasminogen to fibrin and its activation to plasmin.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transcription factor (TF)
            R2R3-MYB (AN2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of AN2
                      Induced Change Aminocaproic acid concentration: increase (FC = 2.59)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of AN2 leads to the increase of aminocaproic acid levels compared with control group.
References
1 Comprehensive Influences of Overexpression of a MYB Transcriptor Regulating Anthocyanin Biosynthesis on Transcriptome and Metabolome of Tobacco Leaves. Int J Mol Sci. 2019 Oct 16;20(20):5123.

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