Details of Metabolite

General Information of MET (ID: META00807)
Name N'-Formylkynurenine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
3-(2-Formamidobenzoyl)alanine; 3-(N-Formylanthraniloyl)-alanine; Formylkynurenine; N-Formyl-L-kynurenine', N'-formylkynurenine, (R)-isomer, N'-formylkynurenine, (S)-isomer, 'N-Formylkynurenine; N-Formyl-delta-kynurenine; alpha-Amino-2-(formylamino)-gamma-oxo-benzenebutanoate; alpha-Amino-2-(formylamino)-gamma-oxo-benzenebutanoic acid', N'-formyl-kynurenine, 'N-Formyl-D-kynurenine
Source Endogenous;Yeast Metabolite;Food
Structure Type   Carbonyl compounds  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic oxygen compounds
Organooxygen compounds
Carbonyl compounds
PubChem CID
910
HMDB ID
HMDB0001200
Formula
C11H12N2O4
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C02406
ChEBI ID
18377
FooDB ID
FDB022486
ChemSpider ID
886
Physicochemical Properties Molecular Weight 236.22 Topological Polar Surface Area 110
XlogP -2.3 Complexity 306
Heavy Atom Count 17 Rotatable Bond Count 5
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 5
Function
Plays an especially improtant role in photobiological responses. The excited states of N-formylkynurenine react to produce hydroxyl radicals.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transcription factor (TF)
            R2R3-MYB (AN2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of AN2
                      Induced Change N'-Formylkynurenine concentration: decrease (FC = 0.45)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of AN2 leads to the decrease of N'-formylkynurenine levels compared with control group.
References
1 Comprehensive Influences of Overexpression of a MYB Transcriptor Regulating Anthocyanin Biosynthesis on Transcriptome and Metabolome of Tobacco Leaves. Int J Mol Sci. 2019 Oct 16;20(20):5123.

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