Details of Metabolite

General Information of MET (ID: META00784)
Name 4-Hydroxybenzoic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
4-Carboxyphenol; 4-Hydroxy-benzoate; 4-Hydroxy-benzoesaeure; 4-Hydroxy-benzoic acid; 4-Hydroxybenzoate; 4-Hydroxybenzoic acid, calcium salt; 4-Hydroxybenzoic acid, copper(2+)(1:1) salt; 4-Hydroxybenzoic acid, dilithium salt; 4-Hydroxybenzoic acid, dipotassium salt; 4-Hydroxybenzoic acid, disodium salt; 4-Hydroxybenzoic acid, monopotassium salt; 4-Hydroxybenzoic acid, monosodium salt; 4-Hydroxybenzoic acid, monosodium salt, 11C-labeled; Hydroxybenzenecarboxylate; Hydroxybenzenecarboxylic acid; Hydroxybenzoate; Hydroxybenzoic acid; Para-hydroxybenzoic acid; Paraben-acid; Sodium p-hydroxybenzoate tetrahydrate; p-Carboxyphenol; p-HYDROXYBENZOIC ACID; p-HYDROXYBENZOate; p-Hydroxy-benzoate; p-Hydroxy-benzoic acid; p-Salicylate; p-Salicylic acid
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;Drug;Cosmetic;Food additives;TCM Ingredients;p-Coumaric;acid;Microbial; ; Herbal Ingredients In-Vivo Metabolism
Structure Type   Benzoic acids and derivatives  (Click to Show/Hide the Complete Structure Type Hierarchy)
Benzenoids
Benzene and substituted derivatives
Benzoic acids and derivatives
PubChem CID
135
HMDB ID
HMDB0000500
Formula
C7H6O3
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00156
DrugBank ID
DB04242
ChEBI ID
30763
FooDB ID
FDB010508
ChemSpider ID
132
METLIN ID
5486
Physicochemical Properties Molecular Weight 138.12 Topological Polar Surface Area 57.5
XlogP 1.6 Complexity 125
Heavy Atom Count 10 Rotatable Bond Count 1
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Function
4-Hydroxybenzoic acid, or p-hydroxybenzoic acid, is a phenolic derivative of benzoic acid. It a white crystalline solid that is slightly soluble in water and chloroform, but well soluble in alcohols, ether, and acetone. 4-Hydroxybenzoic acid is a microbial metabolite found in Arthrobacter, Bifidobacterium, Clostridium, Corynebacterium, Eubacterium, Escherichia coli, and Microbulbifer. 4-Hydroxybenzoic acid is a metabolite formed by the gut microflora detected after the consumption of whole grain.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transcription factor (TF)
            R2R3-MYB (AN2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of AN2
                      Induced Change 4-Hydroxybenzoic acid concentration: increase (FC = 7.37)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of AN2 leads to the increase of 4-hydroxybenzoic acid levels compared with control group.
References
1 Comprehensive Influences of Overexpression of a MYB Transcriptor Regulating Anthocyanin Biosynthesis on Transcriptome and Metabolome of Tobacco Leaves. Int J Mol Sci. 2019 Oct 16;20(20):5123.

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