Details of Metabolite

General Information of MET (ID: META00767)
Name 6-Hydroxyindole sulfate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
6-Hydroxyindole sulfate; 6-Hydroxyindole sulfuric acid; 6-Hydroxyindole sulphate; 6-Hydroxyindole sulphuric acid; 6-Hydroxyindolesulfate; 6-Hydroxyindolesulphate
Source Aromatic heteropolycyclic compounds
Structure Type   Arylsulfates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Organic sulfuric acids and derivatives
Arylsulfates
PubChem CID
122198196
HMDB ID
HMDB0240651
Formula
C8H7NO4S
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
133568
ChemSpider ID
58827641
Physicochemical Properties Molecular Weight 213.21 Topological Polar Surface Area 87.8
XlogP 1.7 Complexity 297
Heavy Atom Count 14 Rotatable Bond Count 2
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 4
Function
6-Hydroxyindole sulfate belongs to the class of organic compounds known as arylsulfates. These are organic compounds containing a sulfate group that carries an aryl group through an ether group. 6-Hydroxyindole sulfate has been identified in blood.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Apolipoprotein (Apo)
            Apolipoprotein A-II (APOA2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (-265T >C(rs5082)) of APOA2
                      Induced Change 6-Hydroxyindole sulfate concentration: decrease (FC = 0.61)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Obesity [ICD-11: 5B81]
                      Details It is reported that mutation (-265T >C(rs5082)) of APOA2 leads to the decrease of 6-hydroxyindole sulfate levels compared with control group.
References
1 Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. Am J Clin Nutr. 2018 Jul 1;108(1):188-200.

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