Details of Metabolite

General Information of MET (ID: META00751)
Name Phenyl 2,3-dihydroxybenzoate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Phenyl 2,3-dihydroxybenzoic acid
Source Aromatic homomonocyclic compounds
Structure Type   Depsides and depsidones  (Click to Show/Hide the Complete Structure Type Hierarchy)
Phenylpropanoids and polyketides
Depsides and depsidones
PubChem CID
21184967
HMDB ID
HMDB0135162
Formula
C13H10O4
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 230.22 Topological Polar Surface Area 66.8
XlogP 3.1 Complexity 260
Heavy Atom Count 17 Rotatable Bond Count 3
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 4
Function
Phenyl 2,3-dihydroxybenzoate is a predicted metabolite generated by BioTransformer that is produced by the metabolism of phenyl 2-hydroxybenzoate. It is generated by cyp2a6, cyp2c9, cyp2c19, and cyp2e1 enzymes via a hydroxylation-of-benzene-ortho-to-strongly-edg reaction. This hydroxylation-of-benzene-ortho-to-strongly-edg occurs in humans.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Leukotriene-C4 hydrolase (GGT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (siRNA) of GGT1
                      Induced Change Phenyl 2,3-dihydroxybenzoate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Renal cell carcinoma [ICD-11: 2C90]
                      Details It is reported that knockdown of GGT1 leads to the increase of phenyl 2,3-dihydroxybenzoate levels compared with control group.
References
1 Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6274-E6282.

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