Details of Metabolite

General Information of MET (ID: META00746)
Name 6-Phosphonatooxy-D-gluconate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2,3,4,5-Tetrahydroxy-6-(phosphonooxy)hexanoate; 6-Phospho-D-gluconate; 6-Phospho-D-gluconic acid; 6-Phosphonatooxy-D-gluconic acid
Source Aliphatic acyclic compounds
Structure Type   Carbohydrates and carbohydrate conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic oxygen compounds
Organooxygen compounds
Carbohydrates and carbohydrate conjugates
PubChem CID
422
HMDB ID
HMDB0062800
Formula
C6H13O10P
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 276.14 Topological Polar Surface Area 185
XlogP -4.5 Complexity 299
Heavy Atom Count 17 Rotatable Bond Count 7
Hydrogen Bond Donor Count 7 Hydrogen Bond Acceptor Count 10
Function
6-phosphonatooxy-D-gluconate is also known as 6-phospho-D-Gluconic acid. 6-phosphonatooxy-D-gluconate is considered to be soluble (in water) and acidic
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Leukotriene-C4 hydrolase (GGT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (siRNA) of GGT1
                      Induced Change 6-Phosphonatooxy-D-gluconate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Renal cell carcinoma [ICD-11: 2C90]
                      Details It is reported that knockdown of GGT1 leads to the increase of 6-phosphonatooxy-D-gluconate levels compared with control group.
References
1 Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6274-E6282.

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