Details of Metabolite

General Information of MET (ID: META00736)
Name Hepoxilin b3
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(8Z)-10-Hydroxy-10-[(3S)-3-[(2Z)-oct-2-en-1-yl]oxiran-2-yl]deca-5,8-dienoate; 10-Hydroxy-11,12-epoxyeicosa-5,8,14-trienoic acid; 10-Hydroxy-11S,12S-epoxy-5Z,8Z,14Z-eicosatrienoate; EPHETA; Hepoxilin b; 10-Hydroxy-11S,12S-epoxy-5Z,8Z,14Z-eicosatrienoic acid; erythro-Hepoxilin b3; threo-Hepoxilin b3
Source Aliphatic heteromonocyclic compounds
Structure Type   Eicosanoids  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Eicosanoids
HMDB ID
HMDB0062479
Formula
C20H32O4
Structure
2D MOL
Function
10-hydroxy-11S,12S-epoxy-5Z,8Z,14Z-eicosatrienoic acid, also known as Hepoxilin b3 or EPHETA, is classified as a member of the Hepoxilins. Hepoxilins are eicosanoids containing an oxirane group attached to the fatty acyl chain. 10-hydroxy-11S,12S-epoxy-5Z,8Z,14Z-eicosatrienoic acid is considered to be practically insoluble (in water) and acidic
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Lyases (EC 4)
            Hydroperoxide isomerase ALOXE3 (eLOX-3) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Aloxe3
                      Induced Change Hepoxilin b3 concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockout of Aloxe3 leads to the decrease of hepoxilin b3 levels compared with control group.
References
1 Aloxe3 knockout mice reveal a function of epidermal lipoxygenase-3 as hepoxilin synthase and its pivotal role in barrier formation. J Invest Dermatol. 2013 Jan;133(1):172-80.

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