Details of Metabolite

General Information of MET (ID: META00732)
Name 5-Phosphoribosyl-4-carboxy-5-aminoimidazole
Synonyms   Click to Show/Hide Synonyms of This Metabolite
4-Carboxy-5-aminoimidazole ribotide', 5'-Phosphoribosyl-5-amino-4-imidazolecarboxamide, '5-Amino-1-beta-D-ribofuranosylimidazole-4-carboxamide monophosphate', 5-Amino-4-imidazolecarboxamide ribofuranoside 5'-monophosphate, 'AICA Ribonucleotide; 5-Amino-1-{3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl}-1H-imidazole-4-carboxylate; AICA Ribonucleotide, (D-ribofuranosyl)-isomer; AICAR', AICAriboside 5'-monophosphate, 'Aminoimidazole carboxamide ribonucleotide; Z-Nucleotide; ZMP
Source Aromatic heteromonocyclic compounds
Structure Type   Carbohydrates and carbohydrate conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic oxygen compounds
Organooxygen compounds
Carbohydrates and carbohydrate conjugates
PubChem CID
1010
HMDB ID
HMDB0062424
Formula
C9H14N3O9P
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
Physicochemical Properties Molecular Weight 339.2 Topological Polar Surface Area 198
XlogP -3.2 Complexity 473
Heavy Atom Count 22 Rotatable Bond Count 5
Hydrogen Bond Donor Count 6 Hydrogen Bond Acceptor Count 11
Function
5-Phosphoribosyl-4-carboxy-5-aminoimidazole is also known as AICA Ribonucleotide, (D-ribofuranosyl)-isomer or AICAR. 5-Phosphoribosyl-4-carboxy-5-aminoimidazole is considered to be slightly soluble (in water) and acidic
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Leukotriene-C4 hydrolase (GGT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (siRNA) of GGT1
                      Induced Change 5-Phosphoribosyl-4-carboxy-5-aminoimidazole concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Renal cell carcinoma [ICD-11: 2C90]
                      Details It is reported that knockdown of GGT1 leads to the increase of 5-phosphoribosyl-4-carboxy-5-aminoimidazole levels compared with control group.
References
1 Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6274-E6282.

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