Details of Metabolite

General Information of MET (ID: META00731)
Name 1-Tetradecanoyl-sn-glycero-3-phosphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(2R)-2-Hydroxy-3-(phosphonooxy)propyl myristate; (2R)-2-Hydroxy-3-(phosphonooxy)propyl myristic acid; 1-Myristoyl lpa; 1-Myristoyl lysophosphatidate; 1-Myristoyl lysophosphatidic acid; 1-Myristoyl-2-lyso-sn-glycerol 3-phosphatidate; 1-Myristoyl-2-lyso-sn-glycerol 3-phosphatidic acid; 1-Myristoylglycerol 3-phosphate; 1-Myristoylglycerol 3-phosphoric acid; 1-O-Myristoyl-sn-glycerol 3-phosphate; 1-O-Myristoyl-sn-glycerol 3-phosphoric acid; 1-O-Tetradecanoyl-sn-glycerol 3-phosphate; 1-O-Tetradecanoyl-sn-glycerol 3-phosphoric acid; 1-Tetradecanoyl-sn-glycero-3-phosphoric acid; 1-Tetradecanoyl-sn-glycerol 3-phosphate; 1-Tetradecanoyl-sn-glycerol 3-phosphoric acid; 1-Tetradecanoylglycerol 3-phosphate; 1-Tetradecanoylglycerol 3-phosphoric acid; Myristoyl lysophosphatidate; Myristoyl lysophosphatidic acid; PA(14:0/0:0)
Source Aliphatic acyclic compounds
Structure Type   Glycerophosphates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Glycerophospholipids
Glycerophosphates
PubChem CID
9547180
HMDB ID
HMDB0062321
Formula
C17H35O7P
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
62833
ChemSpider ID
7826123
Physicochemical Properties Molecular Weight 382.4 Topological Polar Surface Area 113
XlogP 4 Complexity 370
Heavy Atom Count 25 Rotatable Bond Count 18
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 7
Function
1-tetradecanoyl-sn-glycero-3-phosphate is also known as 1-Myristoyl lysophosphatidic acid or (2R)-2-Hydroxy-3-(phosphonooxy)propyl myristate. 1-tetradecanoyl-sn-glycero-3-phosphate is considered to be practically insoluble (in water) and acidic. 1-tetradecanoyl-sn-glycero-3-phosphate is a glycerophosphate lipid molecule
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Apolipoprotein (Apo)
            Apolipoprotein A-II (APOA2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (-265T >C(rs5082)) of APOA2
                      Induced Change 1-Tetradecanoyl-sn-glycero-3-phosphate concentration: decrease (FC = 0.44)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Obesity [ICD-11: 5B81]
                      Details It is reported that mutation (-265T >C(rs5082)) of APOA2 leads to the decrease of 1-tetradecanoyl-sn-glycero-3-phosphate levels compared with control group.
References
1 Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. Am J Clin Nutr. 2018 Jul 1;108(1):188-200.

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