Details of Metabolite

General Information of MET (ID: META00728)
Name Succinylcarnitine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
O-Succinylcarnitine
Source Aliphatic acyclic compounds
Structure Type   Fatty acid esters  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Fatty acid esters
PubChem CID
131802075
HMDB ID
HMDB0061717
Formula
C11H19NO6
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChemSpider ID
62896353
Physicochemical Properties Molecular Weight 261.269 Topological Polar Surface Area 104
XlogP -0.2 Complexity 315
Heavy Atom Count 18 Rotatable Bond Count 8
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 6
Function
Succinylcarnitine (C4DC) arises from the TCA cycle intermediate succinyl-CoA in plasma and liver. It is an O-acylcarnitine having succinyl as the acyl substituent. It functions as a secondary metabolite, which is a metabolite that is not directly involved in the normal growth, development, or reproduction of an organism. Succinylcarnitine has been identified in the human placenta.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Apolipoprotein (Apo)
            Apolipoprotein A-II (APOA2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (-265T >C(rs5082)) of APOA2
                      Induced Change Succinylcarnitine concentration: decrease (FC = 0.85)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Obesity [ICD-11: 5B81]
                      Details It is reported that mutation (-265T >C(rs5082)) of APOA2 leads to the decrease of succinylcarnitine levels compared with control group.
References
1 Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. Am J Clin Nutr. 2018 Jul 1;108(1):188-200.

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