General Information of MET (ID: META00727)
Name Glutamic acid gamma-methyl ester
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(2S)-2-Amino-5-methoxy-5-oxo-pentanoic acid; (2S)-2-Amino-5-methoxy-5-oxopentanoate; (S)-2-Aminopentanedioic acid 5-methyl ester; (S)-Glutamic acid 5-methyl ester; 4(S)-Carboxy-4-aminobutanoic acid methyl ester; 5-Methyl L-glutamate; Glutamic acid 5-methyl ester; L-Glutamate 5-methyl ester; PGMGT; PMLG Polymer; Poly(gamma-methyl L-glutamate); Poly(gamma-methyl-L-glutamate); Poly-gamma-methylglutamate; Poly-gamma-methylglutamic acid; gamma-Methyl (S)-glutamate
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
68662
HMDB ID
HMDB0061715
Formula
C6H11NO4
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=68662"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChemSpider ID
61916
Physicochemical Properties Molecular Weight 161.16 Topological Polar Surface Area 89.6
XlogP -3.4 Complexity 157
Heavy Atom Count 11 Rotatable Bond Count 5
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 5
Function
Glutamate gamma-methyl ester, also known as L-Glutamic acid 5-methyl ester or g-methyl-L-glutamate (CAS# 1499-55-4) is a white amorphous powder and soluble in water. Its melting point is 182 degree Celsius and should be stored at 2-8 degree Celsius Glutamic acid gamma-methyl ester has been identified in the human placenta.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Apolipoprotein (Apo)
            Apolipoprotein A-II (APOA2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (-265T >C(rs5082)) of APOA2
                      Induced Change Glutamic acid gamma-methyl ester concentration: decrease (FC = 0.21)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Obesity [ICD-11: 5B81]
                      Details It is reported that mutation (-265T >C(rs5082)) of APOA2 leads to the decrease of glutamic acid gamma-methyl ester levels compared with control group.
References
1 Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. Am J Clin Nutr. 2018 Jul 1;108(1):188-200.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.