General Information of MET (ID: META00725)
Name Methylphosphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Dihydrogen methyl phosphate; Dihydrogen methyl phosphoric acid; MMP; Methyl dihydrogen phosphate; Methyl dihydrogen phosphoric acid; Methyl phosphate; Methyl phosphoric acid; Methylphosphate; Methylphosphoric acid; Monomethyl dihydrogen phosphate; Monomethyl dihydrogen phosphoric acid; Monomethyl phosphate; Monomethyl phosphoric acid; O-Methyl phosphate; O-Methyl phosphoric acid; Phosphate monomethyl ester; Phosphoric acid monomethyl ester
Structure Type   Phosphate esters  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Organic phosphoric acids and derivatives
Phosphate esters
PubChem CID
13130
HMDB ID
HMDB0061711
Formula
CH5O4P
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
340824
ChemSpider ID
12578
Physicochemical Properties Molecular Weight 112.02 Topological Polar Surface Area 66.8
XlogP -1.6 Complexity 71.6
Heavy Atom Count 6 Rotatable Bond Count 1
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 4
Function
Methylphosphate, also known as monomethyl phosphate or MMP, belongs to the class of organic compounds known as monoalkyl phosphates. These are organic compounds containing a phosphate group that is linked to exactly one alkyl chain. Methylphosphate is a moderately acidic compound (based on its pKa). Methylphosphate is a methyl ester of phosphoric acid. It is a colourless, nonvolatile liquid, and it has some specialized uses in the production of other compounds.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Sulfatase sulf-1 (SULF1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (shRNA) of SULF1
                      Induced Change Methylphosphate concentration: decrease (FC = 0.64)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Ovarian cancer [ICD-11: 2C73]
                      Details It is reported that knockdown of SULF1 leads to the decrease of methylphosphate levels compared with control group.
References
1 Erratum to: Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab. 2014 Nov 4;2:24.

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