Details of Metabolite

General Information of MET (ID: META00715)
Name DL-Glutamate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2-Aminoglutarate; 2-Aminoglutaric acid; Aluminum L glutamate; Aluminum L-glutamate; D Glutamate; D-Glutamate; DL-Glutamate; DL-Glutamic acid; DL-Glutaminate; DL-Glutaminic acid; E; Glu; Glutamate; Glutamate, potassium; Glutamic acid; Glutamic acid, (D)-isomer; Glutaminate; Glutaminic acid; Glutaminsaeure; L Glutamate; L Glutamic acid; L-Glutamate; L-Glutamate, aluminum; L-Glutamic acid; Potassium glutamate
Source Food;Microbial
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
611
HMDB ID
HMDB0060475
Formula
C5H9NO4
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00302
ChEBI ID
18237
FooDB ID
FDB012536
Physicochemical Properties Molecular Weight 147.13 Topological Polar Surface Area 101
XlogP -3.7 Complexity 145
Heavy Atom Count 10 Rotatable Bond Count 4
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 5
Function
This compound belongs to the family of Alpha Amino Acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon).
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Dicarboxylate/amino acid:cation symporter (DAACS)
            Excitatory amino acid transporter 1 (SLC1A3) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of SLC1A3
                      Induced Change DL-Glutamate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLC1A3 leads to the increase of DL-Glutamate levels compared with control group.
            Excitatory amino acid transporter 2 (SLC1A2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of SLC1A2
                      Induced Change DL-Glutamate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLC1A2 leads to the increase of DL-Glutamate levels compared with control group.
            Excitatory amino acid transporter 3 (SLC1A1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of SLC1A1
                      Induced Change DL-Glutamate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLC1A1 leads to the increase of DL-Glutamate levels compared with control group.
            Excitatory amino acid transporter 4 (SLC1A6) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of SLC1A6
                      Induced Change DL-Glutamate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLC1A6 leads to the increase of DL-Glutamate levels compared with control group.
References
1 Caveolin-1 Sensitivity of Excitatory Amino Acid Transporters EAAT1, EAAT2, EAAT3, and EAAT4. J Membr Biol. 2016 Jun;249(3):239-49.

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