Details of Metabolite

General Information of MET (ID: META00712)
Name 4-Hydroxyphenyl acetate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
1,4-Benzenediol, monoacetate; 1,4-Benzenediol, monoacetic acid; 4-Acetoxyphenol; 4-Hydroxyphenyl acetic acid; 4-Hydroxyphenylacetate; 4-Hydroxyphenylacetic acid; Hydroquinone monoacetate; Hydroquinone monoacetic acid
Structure Type   Phenol esters  (Click to Show/Hide the Complete Structure Type Hierarchy)
Benzenoids
Phenol esters
PubChem CID
96009
HMDB ID
HMDB0060390
Formula
C8H8O3
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C13636
ChEBI ID
31128
Physicochemical Properties Molecular Weight 152.15 Topological Polar Surface Area 46.5
XlogP 0.8 Complexity 136
Heavy Atom Count 11 Rotatable Bond Count 2
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3
Function
This compound belongs to the family of Phenol Esters. These are aromatic compounds containing a benzene ring substituted by an hydroxyl group and an ester group.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Apolipoprotein (Apo)
            Apolipoprotein A-II (APOA2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (-265T >C(rs5082)) of APOA2
                      Induced Change 4-Hydroxyphenyl acetate concentration: decrease (FC = 0.42)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Obesity [ICD-11: 5B81]
                      Details It is reported that mutation (-265T >C(rs5082)) of APOA2 leads to the decrease of 4-hydroxyphenyl acetate levels compared with control group.
References
1 Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. Am J Clin Nutr. 2018 Jul 1;108(1):188-200.

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