Details of Metabolite

General Information of MET (ID: META00703)
Name Guanosine 3',5'-bis(diphosphate)
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Guanosine 3'-diphosphate 5'-diphosphate, Guanosine 5'-diphosphate,3'-diphosphate, GUANOSINE-5',3'-tetraphosphATE, Guanosine 3'-diphosphoric acid 5'-diphosphoric acid, Guanosine 5'-diphosphoric acid,3'-diphosphoric acid, GUANOSINE-5',3'-tetraphosphoric acid, Guanosine 3',5'-bis(diphosphoric acid), 3'-Diphosphate 5'-diphosphate, guanosine, 5'-Diphosphate 3'-diphosphate, guanosine, 'Guanosine tetraphosphate', Guanosine 5'-diphosphate 3'-diphosphate, 'Tetraphosphate, guanosine', 3'-Diphosphate, guanosine 5'-diphosphate, 5'-Diphosphate, guanosine 3'-diphosphate, Guanosine 3' diphosphate 5' diphosphate, Guanosine 5' diphosphate 3' diphosphate
Source Escherichia Coli Metabolite;Microbial
Structure Type   Phenylpyruvic acid derivatives  (Click to Show/Hide the Complete Structure Type Hierarchy)
Benzenoids
Benzene and substituted derivatives
Phenylpyruvic acid derivatives
PubChem CID
439450
HMDB ID
HMDB0059638
Formula
C10H17N5O17P4
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C01228
DrugBank ID
DB04022
ChEBI ID
17633
ChemSpider ID
388557
Physicochemical Properties Molecular Weight 603.16 Topological Polar Surface Area 341
XlogP -7.7 Complexity 1090
Heavy Atom Count 36 Rotatable Bond Count 10
Hydrogen Bond Donor Count 9 Hydrogen Bond Acceptor Count 18
Function
Guanosine 3',5'-bis(diphosphate) is part of the Purine metabolism pathway. It is a substrate for: Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Leukotriene-C4 hydrolase (GGT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (siRNA) of GGT1
                      Induced Change Guanosine 3',5'-bis(diphosphate) concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Renal cell carcinoma [ICD-11: 2C90]
                      Details It is reported that knockdown of GGT1 leads to the increase of guanosine 3',5'-bis(diphosphate) levels compared with control group.
References
1 Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6274-E6282.

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