Details of Metabolite

General Information of MET (ID: META00701)
Name Riboflavin cyclic-4',5'-phosphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
CFMN; Cyclic FMN', Riboflavin cyclic-4',5'-phosphoric acid, Riboflavin cyclic 4',5'-phosphoric acid; Cyclic flavin mononucleotide
Source Food
Structure Type   Alloxazines and isoalloxazines  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organoheterocyclic compounds
Pteridines and derivatives
Alloxazines and isoalloxazines
PubChem CID
11026517
HMDB ID
HMDB0059614
Formula
C17H19N4O8P
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C16071
ChEBI ID
15045
FooDB ID
FDB031146
Physicochemical Properties Molecular Weight 438.3 Topological Polar Surface Area 170
XlogP -1.6 Complexity 863
Heavy Atom Count 30 Rotatable Bond Count 4
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 9
Function
Riboflavin cyclic-4',5'-phosphate is part of the Glycerolipid metabolism, and RIG-I-like receptor signaling pathway pathways. It is a substrate for: Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing).
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transferases (EC 2)
            Succinate-hydroxymethylglutarate CoA-transferase (SUGCT) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Sugct
                      Induced Change Riboflavin cyclic-4',5'-phosphate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Diabetes mellitus [ICD-11: 5A14]
                      Details It is reported that knockout of Sugct leads to the increase of riboflavin cyclic-4',5'-phosphate levels compared with control group.
References
1 Knockout of the non-essential gene SUGCT creates diet-linked, age-related microbiome disbalance with a diabetes-like metabolic syndrome phenotype. Cell Mol Life Sci. 2020 Sep;77(17):3423-3439.

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