Details of Metabolite

General Information of MET (ID: META00699)
Name 6-O-p-Coumaroyl-D-glucose
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(3,4,5,6-Tetrahydroxyoxan-2-yl)methyl (2E)-3-(4-hydroxyphenyl)prop-2-enoic acid
Source Food
Structure Type   Hydroxycinnamic acids and derivatives  (Click to Show/Hide the Complete Structure Type Hierarchy)
Phenylpropanoids and polyketides
Cinnamic acids and derivatives
Hydroxycinnamic acids and derivatives
PubChem CID
13915664
HMDB ID
HMDB0039169
Formula
C15H18O8
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
FooDB ID
FDB018696
Physicochemical Properties Molecular Weight 326.3 Topological Polar Surface Area 137
XlogP -0.8 Complexity 418
Heavy Atom Count 23 Rotatable Bond Count 5
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 8
Function
6-O-p-Coumaroyl-D-glucose is found in green vegetables. 6-O-p-Coumaroyl-D-glucose is isolated from various commercial rhubarbs (Rheum sp.).
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Glucose-6-phosphatase 3 (G6PC3) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of G6pc3
                      Induced Change 6-O-p-Coumaroyl-D-glucose concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Neutropenia [ICD-11: 4B00]
                      Details It is reported that knockout of G6pc3 leads to the decrease of 6-o-p-Coumaroyl-D-glucose levels compared with control group.
References
1 Failure to eliminate a phosphorylated glucose analog leads to neutropenia in patients with G6PT and G6PC3 deficiency. Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1241-1250.

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