General Information of MET (ID: META00674)
Name Valylvaline
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Di-valine; H-L-Val-L-val-OH; H-Val-val-OH; L-Val-L-val; L-Valyl-L-valine; N-L-Valyl-L-valine; N-Valylvaline; V-V; V-V Dipeptide; VV Dipeptide; Val-val; Valine valine dipeptide; Valine-valine dipeptide; Valyl-valine; Valylvaline
Source Aliphatic acyclic compounds
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
107475
HMDB ID
HMDB0029140
Formula
C10H20N2O3
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
73704
ChemSpider ID
96710
Physicochemical Properties Molecular Weight 216.28 Topological Polar Surface Area 92.4
XlogP -2.8 Complexity 239
Heavy Atom Count 15 Rotatable Bond Count 5
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 4
Function
Valylvaline is a dipeptide composed of two valine residues. It is an incomplete breakdown product of protein digestion or protein catabolism. Dipeptides are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. Some dipeptides are known to have physiological or cell-signalling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Sulfatase sulf-1 (SULF1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (shRNA) of SULF1
                      Induced Change Valylvaline concentration: decrease (FC = 0.32 / 0.35)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Ovarian cancer [ICD-11: 2C73]
                      Details It is reported that knockdown of SULF1 leads to the decrease of valylvaline levels compared with control group.
References
1 Erratum to: Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab. 2014 Nov 4;2:24.

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