General Information of MET (ID: META00673)
Name Valylserine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
L-Val-L-ser; L-Valyl-L-serine; N-L-Valyl-L-serine; N-Valylserine; V-S dipeptide; VS; VS dipeptide; Val-Ser; Valine serine dipeptide; Valine-serine dipeptide; Valyl-serine; Valylserine
Source Aliphatic acyclic compounds
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
6992639
HMDB ID
HMDB0029136
Formula
C8H16N2O4
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=6992639"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
75021
ChemSpider ID
5360764
Physicochemical Properties Molecular Weight 204.22 Topological Polar Surface Area 117
XlogP -2.7 Complexity 212
Heavy Atom Count 14 Rotatable Bond Count 4
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 4
Function
Valylserine is a dipeptide composed of valine and serine. It is an incomplete breakdown product of protein digestion or protein catabolism. Dipeptides are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. Some dipeptides are known to have physiological or cell-signalling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Sulfatase sulf-1 (SULF1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (shRNA) of SULF1
                      Induced Change Valylserine concentration: decrease (FC = 0.31 / 0.31)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Ovarian cancer [ICD-11: 2C73]
                      Details It is reported that knockdown of SULF1 leads to the decrease of valylserine levels compared with control group.
References
1 Erratum to: Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab. 2014 Nov 4;2:24.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.