General Information of MET (ID: META00670)
Name Serylphenylalanine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
3-Phenyl-N-serylalanine; L-3-Phenyl-N-serylalanine; L-Ser-L-phe; L-Seryl-L-phenylalanine; N-L-Seryl-L-phenylalanine; N-Serylphenylalanine; S-F Dipeptide; SF; SF Dipeptide; Ser-phe; Serine phenylalanine dipeptide; Serine-phenylalanine dipeptide; Serinyl-phenylalanine; Serinylphenylalanine; Seryl-phenylalanine
Source Endogenous;Endogenous
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
7009597
HMDB ID
HMDB0029046
Formula
C12H16N2O4
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
71029
Physicochemical Properties Molecular Weight 252.27 Topological Polar Surface Area 117
XlogP -2 Complexity 284
Heavy Atom Count 18 Rotatable Bond Count 5
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 4
Function
Serylphenylalanine is a dipeptide composed of serine and phenylalanine. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Sulfatase sulf-1 (SULF1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (shRNA) of SULF1
                      Induced Change Serylphenylalanine concentration: decrease (FC = 0.07 / 0.15)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Ovarian cancer [ICD-11: 2C73]
                      Details It is reported that knockdown of SULF1 leads to the decrease of serylphenylalanine levels compared with control group.
References
1 Erratum to: Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab. 2014 Nov 4;2:24.

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