General Information of MET (ID: META00666)
Name Leucylalanine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
L-A; L-A dipeptide; L-Leu-L-ala; L-Leucyl-L-alanine; LA; LA dipeptide; Leu-Ala; Leucine alanine dipeptide; Leucine-alanine dipeptide; Leucyl-alanine; Leucylalanine; N-L-Leucyl-L-alanine; N-Leucylalanine
Source Aliphatic acyclic compounds
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
81721
HMDB ID
HMDB0028922
Formula
C9H18N2O3
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
73527
ChemSpider ID
73739
Physicochemical Properties Molecular Weight 202.25 Topological Polar Surface Area 92.4
XlogP -2.8 Complexity 216
Heavy Atom Count 14 Rotatable Bond Count 5
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 4
Function
Leucylalanine is a dipeptide composed of leucine and alanine. It is an incomplete breakdown product of protein digestion or protein catabolism. Dipeptides are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. Some dipeptides are known to have physiological or cell-signalling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Sulfatase sulf-1 (SULF1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (shRNA) of SULF1
                      Induced Change Leucylalanine concentration: decrease (FC = 0.47 / 0.52)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Ovarian cancer [ICD-11: 2C73]
                      Details It is reported that knockdown of SULF1 leads to the decrease of leucylalanine levels compared with control group.
References
1 Erratum to: Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab. 2014 Nov 4;2:24.

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