Details of Metabolite

General Information of MET (ID: META00657)
Name Bumetanide
Synonyms   Click to Show/Hide Synonyms of This Metabolite
3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoate; 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid; 3-(Aminosulphonyl)-5-(butylamino)-4-phenoxybenzoate; 3-(Aminosulphonyl)-5-(butylamino)-4-phenoxybenzoic acid; 3-Butylamino-4-(phenoxy)-5-sulfamoylbenzoate; 3-Butylamino-4-(phenoxy)-5-sulfamoylbenzoic acid; 3-Butylamino-4-(phenoxy)-5-sulphamoylbenzoate; 3-Butylamino-4-(phenoxy)-5-sulphamoylbenzoic acid; 3-Butylamino-4-phenoxy-5-sulfamoyl-benzoate; 3-Butylamino-4-phenoxy-5-sulfamoyl-benzoic acid; 3-Butylamino-4-phenoxy-5-sulfamoylbenzoate; 3-Butylamino-4-phenoxy-5-sulfamoylbenzoic acid; 3-Butylamino-4-phenoxy-5-sulphamoyl-benzoate; 3-Butylamino-4-phenoxy-5-sulphamoyl-benzoic acid; 3-Butylamino-4-phenoxy-5-sulphamoylbenzoate; 3-Butylamino-4-phenoxy-5-sulphamoylbenzoic acid; AstraZeneca brand OF bumetanide; Atlantis brand OF bumetanide; Bumedyl; Bumetanida; Bumetanide astrazeneca brand; Bumetanide atlantis brand; Bumetanide farmacusi brand; Bumetanide grossmann brand; Bumetanide leo brand; Bumetanide roche brand; Bumetanide senosiain brand; Bumetanidum; Bumethanide; Bumex; Burinex; Drenural; Farmacusi brand OF bumetanide; Fordiuran; Grossmann brand OF bumetanide; Leo brand OF bumetanide; Miccil; Roche brand OF bumetanide; Senosiain brand OF bumetanide
Source Drug
Structure Type   Diphenylethers  (Click to Show/Hide the Complete Structure Type Hierarchy)
Benzenoids
Benzene and substituted derivatives
Diphenylethers
PubChem CID
2471
HMDB ID
HMDB0015024
Formula
C17H20N2O5S
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
DrugBank ID
DB00887
ChEBI ID
3213
ChemSpider ID
2377
Physicochemical Properties Molecular Weight 364.4 Topological Polar Surface Area 127
XlogP 2.8 Complexity 528
Heavy Atom Count 25 Rotatable Bond Count 8
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 7
Function
Bumetanide is only found in individuals that have used or taken this drug. It is a sulfamyl diuretic.Bumetanide interferes with renal cAMP and/or inhibits the sodium-potassium ATPase pump. Bumetanide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle, altering electrolyte transfer in the proximal tubule. This results in excretion of sodium, chloride, and water and, hence, diuresis.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Sodium/anion cotransporter (SAC)
            Sodium-dependent phosphate transport 4 (SLC17A3) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of SLC17A3
                      Induced Change Bumetanide concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of SLC17A3 leads to the increase of bumetanide levels compared with control group.
References
1 Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate. J Biol Chem. 2010 Nov 5;285(45):35123-32.

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