Details of Metabolite

General Information of MET (ID: META00654)
Name Chlordiazepoxide
Synonyms   Click to Show/Hide Synonyms of This Metabolite
7-Chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepin-4-oxide; CDP; Chlordiazepoxide base; Chlordiazepoxidum; Clopoxide; Helogaphen; Libritabs; Methaminodiazepoxide; Multum; Risolid; Silibrin; Tropium
Source Drug
Structure Type   1,4-benzodiazepines  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organoheterocyclic compounds
Benzodiazepines
1,4-benzodiazepines
HMDB ID
HMDB0014618
Formula
C16H14ClN3O
Structure
2D MOL
DrugBank ID
DB00475
ChEBI ID
3611
ChemSpider ID
10248513
Function
Chlordiazepoxide is only found in individuals that have used or taken this drug. It is an anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal. Chlordiazepoxide binds to stereospecific benzodiazepine (BZD) binding sites on GABA (A) receptor complexes at several sites within the central nervous system, including the limbic system and reticular formation. This results in an increased binding of the inhibitory neurotransmitter GABA to the GABA(A) receptor.BZDs, therefore, enhance GABA-mediated chloride influx through GABA receptor channels, causing membrane hyperpolarization. The net neuro-inhibitory effects result in the observed sedative, hypnotic, anxiolytic, and muscle relaxant properties.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Mitochondrial carrier (MC)
            Solute carrier family 25 member 33 (SLC25A33) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Recombinant protein addition of SLC25A33
                      Induced Change Chlordiazepoxide concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that recombinant protein addition of SLC25A33 leads to the increase of chlordiazepoxide levels compared with control group.
            Solute carrier family 25 member 36 (SLC25A36) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Recombinant protein addition of SLC25A36
                      Induced Change Chlordiazepoxide concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that recombinant protein addition of SLC25A36 leads to the increase of chlordiazepoxide levels compared with control group.
References
1 The human SLC25A33 and SLC25A36 genes of solute carrier family 25 encode two mitochondrial pyrimidine nucleotide transporters. J Biol Chem. 2014 Nov 28;289(48):33137-48.

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