General Information of MET (ID: META00647)
Name 10Z-Nonadecenoic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(10Z)-10-Nonadecenoic acid; (Z)-10-Nonadecenoic acid; 10(Z)-Nonadecenoate; 10(Z)-Nonadecenoic acid; 10-Nonadecenoate; 10-Nonadecenoate (19:1n9); 10-Nonadecenoic acid; 10-Nonadecenoic acid (19:1n9); 10Z-Nonadecenoate; FA(19:1(10Z)); Nonadeca-10(Z)-enoic acid; cis-10-Nonadecenoic acid
Source Endogenous;Fatty acyls;Food;Microbial
Structure Type   Fatty acids and conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Fatty acids and conjugates
PubChem CID
5312513
HMDB ID
HMDB0013622
Formula
C19H36O2
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
83051
FooDB ID
FDB029599
ChemSpider ID
4471938
Physicochemical Properties Molecular Weight 296.5 Topological Polar Surface Area 37.3
XlogP 7.1 Complexity 246
Heavy Atom Count 21 Rotatable Bond Count 16
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 2
Function
10Z-Nonadecenoic acid is a monounsaturated fatty acid that has a C19 chain as a backbone and a cis double bond at the C10 position. It is a member of the class of compounds known as long-chain fatty acids. Long-chain fatty acids are fatty acids with an aliphatic tail that contains between 13 and 21 carbon atoms. 10Z-Nonadecenoic acid is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). 10Z-Nonadecenoic acid can be found in blood and feces. Within the cell, 10Z-nonadecenoic acid is primarily located in the membrane (predicted from logP). It can also be found in the extracellular space.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Sulfatase sulf-1 (SULF1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (shRNA) of SULF1
                      Induced Change 10Z-Nonadecenoic acid concentration: increase (FC = 4.78 / 7.34)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Ovarian cancer [ICD-11: 2C73]
                      Details It is reported that knockdown of SULF1 leads to the increase of 10Z-nonadecenoic acid levels compared with control group.
References
1 Erratum to: Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab. 2014 Nov 4;2:24.

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