Details of Metabolite

General Information of MET (ID: META00633)
Name Hydroxypropionylcarnitine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Hydroxypropionyl-L-carnitine
Source Endogenous;Fatty acyls;Food
Structure Type   Fatty acid esters  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Fatty acid esters
PubChem CID
53481699
HMDB ID
HMDB0013125
Formula
C10H19NO5
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
FooDB ID
FDB029298
Physicochemical Properties Molecular Weight 441.6 Topological Polar Surface Area 86.7
XlogP 7 Complexity 493
Heavy Atom Count 31 Rotatable Bond Count 20
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 5
Function
Hydroxypropionylcarnitine is classified as a member of the acyl carnitines. Acyl carnitines are organic compounds containing a fatty acid with the carboxylic acid attached to carnitine through an ester bond. Hydroxypropionylcarnitine is considered to be a slightly soluble (in water) and a weak acidic compound. Hydroxypropionylcarnitine is a fatty ester lipid molecule. Hydroxypropionylcarnitine can be found in blood, cerebrospinal fluid (csf) or urine. Within a cell, Hydroxypropionylcarnitine is primarily located in the extracellular space and near the membrane.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            GTPase KRas (KRAS) Click to Show/Hide the Full List of Regulating Pair(s):   2 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair (1) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of KRAS
                      Induced Change Hydroxypropionylcarnitine concentration: decrease (FC = 0.43)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Lung cancer [ICD-11: 2C25]
                      Details It is reported that overexpression of KRAS leads to the decrease of hydroxypropionylcarnitine levels compared with control group.
               Regulating Pair (2) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of KRAS
                      Induced Change Hydroxypropionylcarnitine concentration: increase (FC = 1.34)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Lung cancer [ICD-11: 2C25]
                      Details It is reported that overexpression of KRAS leads to the increase of hydroxypropionylcarnitine levels compared with control group.
      Transferases (EC 2)
            Carnitine O-palmitoyltransferase 1 (CPT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Knockout of Cpt1c
                      Induced Change Hydroxypropionylcarnitine concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockout of Cpt1c leads to the decrease of hydroxypropionylcarnitine levels compared with control group.
References
1 Capturing the metabolomic diversity of KRAS mutants in non-small-cell lung cancer cells. Oncotarget. 2014 Jul 15;5(13):4722-31.
2 Metabolomic profiling reveals a role for CPT1c in neuronal oxidative metabolism. BMC Biochem. 2012 Oct 25;13:23.

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