Details of Metabolite

General Information of MET (ID: META00620)
Name Ceramide(d18:1/14:0)
Synonyms   Click to Show/Hide Synonyms of This Metabolite
C14 Cer; Ceramide; Ceramide(D18:1/14:0); N-(Myristoyl)ceramide; N-(Tetradecanoyl)-4-sphingenine; N-(Tetradecanoyl)-D-erythro-sphingosine; N-(Tetradecanoyl)-D-sphingosine; N-(Tetradecanoyl)-erythro-4-sphingenine; N-(Tetradecanoyl)-sphing-4-enine; N-(Tetradecanoyl)-sphingenine; N-(Tetradecanoyl)-sphingosine; N-(Tetradecanoyl)ceramide; N-(Tetradecanoyl)sphing-4-enine; N-Myristoylsphing-4-enine; N-Myristoylsphingosine; N-Tetradecanoylsphing-4-enine
Source Endogenous;Sphingolipids;Food
Structure Type   Ceramides  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Sphingolipids
Ceramides
PubChem CID
5282310
HMDB ID
HMDB0011773
Formula
C32H63NO3
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C13916
ChEBI ID
72957
FooDB ID
FDB028443
ChemSpider ID
4445481
Physicochemical Properties Molecular Weight 509.8 Topological Polar Surface Area 69.6
XlogP 11.8 Complexity 480
Heavy Atom Count 36 Rotatable Bond Count 28
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 3
Function
Ceramides (N-acylsphingosine) are one of the hydrolysis byproducts of sphingomyelin by the enzyme sphingomyelinase (sphingomyelin phosphorylcholine phosphohydrolase E.C.3.1.4.12) which has been identified in the subcellular fractions of human epidermis and many other tissues. They can also be synthesized from serine and palmitate in a de novo pathway and are regarded as important cellular signals for inducing apoptosis. Is key in the biosynthesis of glycosphingolipids and gangliosides.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Bone morphogenic antagonist (BMA)
            DAN domain family member 5 (DAND5) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (siRNA) of DAND5
                      Induced Change Ceramide(d18:1/14:0) concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockdown of DAND5 leads to the decrease of ceramide(d18:1/14:0) levels compared with control group.
References
1 Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P. FASEB J. 2006 Sep;20(11):1813-25.

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