Details of Metabolite

General Information of MET (ID: META00616)
Name 3-Hydroxyphenylpyruvic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
3-(3-Hydroxyphenyl)-2-oxopropanoate; 3-HPPA; 3-Hydroxyphenylpyruvate; HPPA; m-Hydroxyphenylpyruvate; m-Hydroxyphenylpyruvic acid
Source Endogenous;Food
Structure Type   Phenylpyruvic acid derivatives  (Click to Show/Hide the Complete Structure Type Hierarchy)
Benzenoids
Benzene and substituted derivatives
Phenylpyruvic acid derivatives
PubChem CID
5318321
HMDB ID
HMDB0011663
Formula
C9H8O4
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
FooDB ID
FDB028354
ChemSpider ID
4476924
Physicochemical Properties Molecular Weight 180.16 Topological Polar Surface Area 74.6
XlogP 0.7 Complexity 212
Heavy Atom Count 13 Rotatable Bond Count 3
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 4
Function
3-Hydroxyphenylpyruvic acid is a keto acid intermediate derived from m-Tyrosine. m-Tyrosine has the ability to cross the blood-brain barrier and is decarboxylated to m-tyramine which stimulates dopamine receptors.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Leukotriene-C4 hydrolase (GGT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (siRNA) of GGT1
                      Induced Change 3-Hydroxyphenylpyruvic acid concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Renal cell carcinoma [ICD-11: 2C90]
                      Details It is reported that knockdown of GGT1 leads to the increase of 3-hydroxyphenylpyruvic acid levels compared with control group.
References
1 Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6274-E6282.

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