Details of Metabolite

General Information of MET (ID: META00615)
Name Glycerophosphoinositol
Synonyms   Click to Show/Hide Synonyms of This Metabolite
1-(sn-glycero-3-phospho)-1D-myo-Inositol; 3-Phosphoglyceroinositol; Glycerophosphoinositol; Glyerophosphoinositol; GroPIns; alpha-Glycerophosphoryl inositol; sn-Glycero-3-phospho-1-inositol
Source Endogenous;Escherichia Coli Metabolite;Food
Structure Type   Glycerophosphoinositols  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Glycerophospholipids
Glycerophosphoinositols
HMDB ID
HMDB0011649
Formula
C9H19O11P
Structure
2D MOL
KEGG ID
C01225
ChEBI ID
18321
FooDB ID
FDB011624
ChemSpider ID
28184592
Function
Glycerophosphoinositol (CAS: 16824-65-0), also known as 1-(sn-glycero-3-phospho)-1D-myo-inositol, is produced through deacylation by phospholipase B of the essential phospholipid phosphatidylinositol. Glycerophosphoinositols are ubiquitous phosphoinositide metabolites involved in the control of several cell functions. They exert their actions both intracellularly and by rapidly equilibrating across the plasma membrane. Their transport is mediated by the Glut2 transporter, the human ortholog of GIT1. Glycerophosphoinositol is a substrate for glycerophosphoinositol inositolphosphodiesterase (EC 3.1.4.43) and is involved in the following reaction: 1-(sn-glycero-3-phospho)-1D-myo-inositol + H2O = glycerol + 1D-myo-inositol 1-phosphate. It is also a substrate for glycerophosphoinositol glycerophosphodiesterase (EC 3.1.4.44) which catalyzes the chemical reaction: 1-(sn-glycero-3-phospho)-1D-myo-inositol + H2O = myo-inositol + sn-glycerol 3-phosphate.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Glycerophosphodiester phosphodiesterase 1 (GDE1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Gde1
                      Induced Change Glycerophosphoinositol concentration: increase (FC = 25)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockout of Gde1 leads to the increase of glycerophosphoinositol levels compared with control group.
References
1 The glycerophospho metabolome and its influence on amino acid homeostasis revealed by brain metabolomics of GDE1(-/-) mice. Chem Biol. 2010 Aug 27;17(8):831-40.

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