Details of Metabolite

General Information of MET (ID: META00614)
Name p-Cresol sulfate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
4-Cresol sulfate; 4-Cresol sulfuric acid; 4-Cresol sulphate; 4-Cresol sulphuric acid; Para-cresol sulfate; Para-cresol sulphate; Sulfate mono-p-tolyl ester; Sulfuric acid mono(p-tolyl) ester (8ci); Sulfuric acid mono-p-tolyl ester; Sulfuric acid, mono(4-methylphenyl) ester; Sulphate mono-p-tolyl ester; Sulphuric acid mono-p-tolyl ester; mono(4-Methylphenyl) sulfate; p-Cresol sulfuric acid; p-Cresol sulphate; p-Cresol sulphuric acid; p-Cresyl sulfate; p-Cresyl sulphate; p-Cresyl-sulfate; p-Cresyl-sulphate; p-Cresylsulfate; p-Cresylsulphate; p-Tolyl sulfate (6ci,7ci); p-Tolyl sulphate (6ci,7ci)
Source Endogenous;Food;Toxins/Pollutant;Microbial
Structure Type   Arylsulfates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Organic sulfuric acids and derivatives
Arylsulfates
PubChem CID
4615423
HMDB ID
HMDB0011635
Formula
C7H8O4S
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
82914
FooDB ID
FDB028333
ChemSpider ID
3806481
Physicochemical Properties Molecular Weight 188.2 Topological Polar Surface Area 72
XlogP 1.3 Complexity 220
Heavy Atom Count 12 Rotatable Bond Count 2
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 4
Function
p-Cresol sulfate is a microbial metabolite that is found in urine and likely derives from secondary metabolism of p-cresol. It appears to be elevated in the urine of individuals with progressive multiple sclerosis. p-Cresol sulfate is the major component of urinary MBPLM (myelin basic protein-like material). p-Cresol sulfate is a small protein-bound molecule that is poorly cleared with dialysis. It has been identified as a uremic toxin according to the European Uremic Toxin Working Group. Uremic toxins include other low-molecular-weight compounds such as indoxyl sulfate, 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid, and asymmetric dimethylarginine. It has also been linked to cardiovascular disease and oxidative injury. Higher levels are associated with overgrowth of intestinal bacteria from Clostridia species, including C. difficile. p-Cresol is generated by the partial breakdown of tyrosine and phenylalanine by a wide range of intestinal obligate or facultative anaerobes, including the genera Bacteroides, Lactobacillus, Enterobacter, Bifidobacterium, and especially Clostridium.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Sulfatase sulf-1 (SULF1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (shRNA) of SULF1
                      Induced Change p-Cresol sulfate concentration: decrease (FC = 0.59)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Ovarian cancer [ICD-11: 2C73]
                      Details It is reported that knockdown of SULF1 leads to the decrease of p-cresol sulfate levels compared with control group.
References
1 Erratum to: Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab. 2014 Nov 4;2:24.

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