Details of Metabolite

General Information of MET (ID: META00612)
Name Cinnamoylglycine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Cinnamoylglycine; N-(1-oxo-3-Phenyl-2-propen-1-yl)-glycine; N-(1-oxo-3-Phenyl-2-propenyl)-glycine; N-Cinnamoyl-glycine; N-Cinnamoylglycine; N-Cinnamylglycine
Source Endogenous;Food
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
709625
HMDB ID
HMDB0011621
Formula
C11H11NO3
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
68616
FooDB ID
FDB028325
ChemSpider ID
618829
Physicochemical Properties Molecular Weight 205.21 Topological Polar Surface Area 66.4
XlogP 1.2 Complexity 255
Heavy Atom Count 15 Rotatable Bond Count 4
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Function
Cinnamoylglycine is known as a urinary metabolite in man although whether it is formed de novo from plant cinnamate or is a plant product excreted. unchanged has not been conclusively demonstrated. When cinnamoylglycine occurs naturally it is probably a food constituent excreted unchanged. It is not found when small quantities (0.5-6 g) of cinnamic acid are fed to man, but by analogy with animal experiments may be produced when much larger quantities are given.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Apolipoprotein (Apo)
            Apolipoprotein A-II (APOA2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (-265T >C(rs5082)) of APOA2
                      Induced Change Cinnamoylglycine concentration: decrease (FC = 0.47)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Obesity [ICD-11: 5B81]
                      Details It is reported that mutation (-265T >C(rs5082)) of APOA2 leads to the decrease of cinnamoylglycine levels compared with control group.
References
1 Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. Am J Clin Nutr. 2018 Jul 1;108(1):188-200.

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