General Information of MET (ID: META00609)
Name MG(18:2(9Z,12Z)/0:0/0:0)
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(S)-1-Monolinolein; (S)-1-O-Linoleoylglycerol; 1-(9Z,12Z)-Octadecadienoyl-sn-glycerol; 1-(9Z,12Z-Octadecadienoyl)-rac-glycerol; 1-(9Z,12Z-Octadecadienoyl)-sn-glycerol; 1-Glyceryl linoleate; 1-LG; 1-Linoleoyl-glycerol; 1-Linoleoyl-sn-monoglyceride; 1-Linoleylglycerol; 1-Monoacylglyceride; 1-Monoacylglycerol; 1-Monolinolein; 1-Monolinoleoyl-rac-glycerol; 1-O-(9Z,12Z-Octadecadienoyl)glycerol; 2,3-Dihydroxypropyl linoleate; 3-O-(9Z,12Z-Octadecadienoyl)glycerol; Glycerol 1-monolinolate; Glyceryl linoleic acid monoester; MAG(18:2); MAG(18:2/0:0); MAG(18:2W6/0:0); MAG(18:2n6/0:0); MG (18:2(N-6)/0:0/0:0); MG(18:2); MG(18:2/0:0); MG(18:2W6/0:0); MG(18:2n6/0:0); MLG CPD; Monolinolein; a-Monoacylglycerol; alpha-Glyceryl linoleate; alpha-Monoacylglycerol; sn-1-Monolinoleoylglycerol
Source Endogenous;Food;Cosmetic;TCM Ingredients
Structure Type   Lineolic acids and derivatives  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Lineolic acids and derivatives
PubChem CID
6436630
HMDB ID
HMDB0011568
Formula
C21H38O4
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
75561
FooDB ID
FDB028281
ChemSpider ID
4941255
Physicochemical Properties Molecular Weight 354.5 Topological Polar Surface Area 66.8
XlogP 5.8 Complexity 350
Heavy Atom Count 25 Rotatable Bond Count 18
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 4
Function
MG(18:2(9Z,12Z)/0:0/0:0) is a monoacylglyceride. A monoglyceride, more correctly known as a monoacylglycerol, is a glyceride consisting of one fatty acid chain covalently bonded to a glycerol molecule through an ester linkage. Monoacylglycerol can be broadly divided into two groups; 1-monoacylglycerols (or 3-monoacylglycerols) and 2-monoacylglycerols, depending on the position of the ester bond on the glycerol moiety. Normally the 1-/3-isomers are not distinguished from each other and are termed 'alpha-monoacylglycerols', while the 2-isomers are beta-monoacylglycerols. Monoacylglycerols are formed biochemically via release of a fatty acid from diacylglycerol by diacylglycerol lipase or hormone sensitive lipase. Monoacylglycerols are broken down by monoacylglycerol lipase. They tend to be minor components only of most plant and animal tissues, and indeed would not be expected to accumulate because their strong detergent properties would have a disruptive effect on membranes. 2-Monoacylglycerols are a major end product of the intestinal digestion of dietary fats in animals via the enzyme pancreatic lipase. They are taken up directly by the intestinal cells and converted to triacylglycerols via the monoacylglycerol pathway before being transported in lymph to the liver. Mono- and Diglycerides are commonly added to commercial food products in small quantities. They act as emulsifiers, helping to mix ingredients such as oil and water that would not otherwise blend well.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Sulfatase sulf-1 (SULF1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (shRNA) of SULF1
                      Induced Change MG(18:2(9Z,12Z)/0:0/0:0) concentration: increase (FC = 1.70 / 3.29)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Ovarian cancer [ICD-11: 2C73]
                      Details It is reported that knockdown of SULF1 leads to the increase of MG(18:2(9Z,12Z)/0:0/0:0) levels compared with control group.
References
1 Erratum to: Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab. 2014 Nov 4;2:24.

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