General Information of MET (ID: META00607)
Name MG(0:0/16:1(9Z)/0:0)
Synonyms   Click to Show/Hide Synonyms of This Metabolite
1-Monoacylglyceride; 1-Monoacylglycerol; 2-(9Z-Hexadecenoyl)-rac-glycerol; 2-Palmitoleoyl-glycerol; MAG(0:0/16:1); MAG(0:0/16:1W7); MAG(0:0/16:1n7); MAG(16:1); MG(0:0/16:1(9Z)/0:0); MG(0:0/16:1); MG(0:0/16:1W7); MG(0:0/16:1n7); MG(16:1); b-Monoacylglycerol; beta-Monoacylglycerol
Source Endogenous;Food
Structure Type   Monoradylglycerols  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Glycerolipids
Monoradylglycerols
PubChem CID
53480960
HMDB ID
HMDB0011534
Formula
C19H36O4
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
87254
FooDB ID
FDB028249
ChemSpider ID
24765769
Physicochemical Properties Molecular Weight 328.5 Topological Polar Surface Area 66.8
XlogP 5.2 Complexity 285
Heavy Atom Count 23 Rotatable Bond Count 17
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 4
Function
MG(0:0/16:1(9Z)/0:0) is a monoacylglyceride. A monoglyceride, more correctly known as a monoacylglycerol, is a glyceride consisting of one fatty acid chain covalently bonded to a glycerol molecule through an ester linkage. Monoacylglycerol can be broadly divided into two groups; 1-monoacylglycerols (or 3-monoacylglycerols) and 2-monoacylglycerols, depending on the position of the ester bond on the glycerol moiety. Normally the 1-/3-isomers are not distinguished from each other and are termed 'alpha-monoacylglycerols', while the 2-isomers are beta-monoacylglycerols. Monoacylglycerols are formed biochemically via release of a fatty acid from diacylglycerol by diacylglycerol lipase or hormone sensitive lipase. Monoacylglycerols are broken down by monoacylglycerol lipase. They tend to be minor components only of most plant and animal tissues, and indeed would not be expected to accumulate because their strong detergent properties would have a disruptive effect on membranes. 2-Monoacylglycerols are a major end product of the intestinal digestion of dietary fats in animals via the enzyme pancreatic lipase. They are taken up directly by the intestinal cells and converted to triacylglycerols via the monoacylglycerol pathway before being transported in lymph to the liver. Mono- and Diglycerides are commonly added to commercial food products in small quantities. They act as emulsifiers, helping to mix ingredients such as oil and water that would not otherwise blend well.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Apolipoprotein (Apo)
            Apolipoprotein A-II (APOA2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (-265T >C(rs5082)) of APOA2
                      Induced Change MG(0:0/16:1(9Z)/0:0) concentration: decrease (FC = 0.48)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Obesity [ICD-11: 5B81]
                      Details It is reported that mutation (-265T >C(rs5082)) of APOA2 leads to the decrease of MG(0:0/16:1(9Z)/0:0) levels compared with control group.
References
1 Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. Am J Clin Nutr. 2018 Jul 1;108(1):188-200.

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