General Information of MET (ID: META00604)
Name LysoPE(0:0/16:0)
Synonyms   Click to Show/Hide Synonyms of This Metabolite
1-Hydroxy-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine; 1-Hydroxy-2-palmitoyl-sn-glycero-3-phosphoethanolamine; 2-Palmitoyl-gpe; 2-Palmitoyl-sn-glycero-3-phosphoethanolamine; 2-Palmitoylglycerophosphoethanolamine; Hexadecanoyl-lysophosphatidylethanolamine; LPE(0:0/16:0); LPE(16:0); Lyso-pe(0:0/16:0); Lyso-pe(16:0); LysoPE(0:0/16:0); LysoPE(16:0); Lysophosphatidylethanolamine(0:0/16:0); Lysophosphatidylethanolamine(16:0); PE(0:0/16:0); Phosphatidylethanolamine (0:0/16:0)
Source Endogenous;Glycerophospholipids;Food
Structure Type   Glycerophosphoethanolamines  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Glycerophospholipids
Glycerophosphoethanolamines
PubChem CID
53480922
HMDB ID
HMDB0011473
Formula
C21H44NO7P
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
131743
FooDB ID
FDB028189
ChemSpider ID
24769354
Physicochemical Properties Molecular Weight 453.5 Topological Polar Surface Area 128
XlogP 2.4 Complexity 451
Heavy Atom Count 30 Rotatable Bond Count 23
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 8
Function
LysoPE(0:0/16:0) is a lysophosphatidylethanolamine or a lysophospholipid. The term 'lysophospholipid' (LPL) refers to any phospholipid that is missing one of its two O-acyl chains. Thus, LPLs have a free alcohol in either the sn-1 or sn-2 position. The prefix 'lyso-' comes from the fact that lysophospholipids were originally found to be hemolytic however it is now used to refer generally to phospholipids missing an acyl chain. LPLs are usually the result of phospholipase A-type enzymatic activity on regular phospholipids such as phosphatidylcholine or phosphatidic acid, although they can also be generated by the acylation of glycerophospholipids or the phosphorylation of monoacylglycerols. Some LPLs serve important signaling functions such as lysophosphatidic acid. Lysophosphatidylethanolamines (LPEs) can function as plant growth regulators with several diverse uses. (LPEs) are approved for outdoor agricultural use to accelerate ripening and improve the quality of fresh produce. They are also approved for indoor use to preserve stored crops and commercial cut flowers. As a breakdown product of phosphatidylethanolamine (PE), LPE is present in cells of all organisms.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Sulfatase sulf-1 (SULF1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (shRNA) of SULF1
                      Induced Change LysoPE(0:0/16:0) concentration: decrease (FC = 0.30)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Ovarian cancer [ICD-11: 2C73]
                      Details It is reported that knockdown of SULF1 leads to the decrease of lysoPE(0:0/16:0) levels compared with control group.
References
1 Erratum to: Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab. 2014 Nov 4;2:24.

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