Details of Metabolite

General Information of MET (ID: META00597)
Name CerP(d18:1/16:0)
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Ceramide phosphate; Ceramide phosphate(D18:1/16:0); N-(Hexadecanoyl)-1-phosphate-4-sphingenine; N-(Hexadecanoyl)-1-phosphate-D-erythro-sphingosine; N-(Hexadecanoyl)-1-phosphate-D-sphingosine; N-(Hexadecanoyl)-1-phosphate-erythro-4-sphingenine; N-(Hexadecanoyl)-1-phosphate-sphing-4-enine; N-(Hexadecanoyl)-1-phosphate-sphingenine; N-(Hexadecanoyl)-1-phosphate-sphingosine; N-(Hexadecanoyl)-sphing-4-enine-1-phosphate; N-Hexadecanoylsphing-4-enine-1-phosphate; N-Hexadecanoylsphing-4-enine-1-phosphoric acid; N-Palmitoylsphing-4-enine-1-phosphate; N-Palmitoylsphing-4-enine-1-phosphoric acid; N-Palmitoylsphingosine 1-phosphate; N-Palmitoylsphingosine 1-phosphoric acid; [(e,2S,3R)-2-(Hexadecanoylamino)-3-hydroxyoctadec-4-enyl] dihydrogen phosphate
Source Aliphatic acyclic compounds
Structure Type   Phosphosphingolipids  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Sphingolipids
Phosphosphingolipids
PubChem CID
5283581
HMDB ID
HMDB0010700
Formula
C34H68NO6P
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
73145
FooDB ID
FDB027850
ChemSpider ID
4446694
Physicochemical Properties Molecular Weight 617.9 Topological Polar Surface Area 116
XlogP 11.8 Complexity 668
Heavy Atom Count 42 Rotatable Bond Count 32
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 6
Function
CerP(d18:1/16:0) is a ceramide 1-phosphate belonging to the sphingolipid class of molecules. Ceramides are amides of fatty acids with long-chain di- or trihydroxy bases, the commonest in animals being sphingosine and in plants phytosphingosine. The acyl group of ceramides is generally a long-chain saturated or monounsaturated fatty acid. The most frequent fatty acids found in animal ceramides are 18:0, 24:0 and 24:1(n-9). Ceramide 1-phosphates are produced by phosphorylation of ceramide by a specific ceramide kinase. Ceramide-1-phosphate was shown to be a specific and potent inducer of arachidonic acid and prostanoid synthesis in cells through the translocation and activation of the cytoplasmic phospholipase A2.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Bone morphogenic antagonist (BMA)
            DAN domain family member 5 (DAND5) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (siRNA) of DAND5
                      Induced Change CerP(d18:1/16:0) concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockdown of DAND5 leads to the decrease of cerP(d18:1/16:0) levels compared with control group.
References
1 Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P. FASEB J. 2006 Sep;20(11):1813-25.

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