Details of Metabolite

General Information of MET (ID: META00596)
Name Ceramide(t18:0/16:0)
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Ceramide; Ceramide (t18:0/16:0); Ceramide(t18:0/16:0); N-(Hexadecanoyl)-4R-hydroxy-D-erythro-sphinganine; N-(Hexadecanoyl)-4R-hydroxy-dihydrosphingosine; N-(Hexadecanoyl)-4R-hydroxy-sphinganine; N-[(2S,3S)-1,3,4-Trihydroxyoctadecan-2-yl]hexadecanimidate
Source Aliphatic acyclic compounds
Structure Type   Ceramides  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Sphingolipids
Ceramides
PubChem CID
53480650
HMDB ID
HMDB0010697
Formula
C34H69NO4
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
FooDB ID
FDB027847
ChemSpider ID
24765759
Physicochemical Properties Molecular Weight 555.9 Topological Polar Surface Area 89.8
XlogP 12.2 Complexity 502
Heavy Atom Count 39 Rotatable Bond Count 31
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 4
Function
Cer(t18:0/16:0) belongs to the class of phytoceramides (N-Acyl-4-hydroxysphinganine), which are involved in sphingolipid metabolism. Phytoceramides are generated from dihydroceramides via the enzyme C4-hydroxylase [EC:1.14.-.-], and are then converted to phytosphingosine via the enzyme N-acylsphingosine amidohydrolase [EC:3.5.1.23].
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Alkaline ceramidase 1 (ACER1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Acer1
                      Induced Change Ceramide(t18:0/16:0) concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockout of Acer1 leads to the increase of ceramide(t18:0/16:0) levels compared with control group.
References
1 Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells. Stem Cell Reports. 2017 Nov 14;9(5):1488-1500.

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