Details of Metabolite

General Information of MET (ID: META00562)
Name 4-Hydroxyphenylacetylglutamic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(2S)-2-{[1-hydroxy-2-(4-hydroxyphenyl)ethylidene]amino}pentanedioate; 4-Hydroxyphenylacetylglutamate; 4-Hydroxyphenylacetylglutamic acid; p-Hydroxyphenylacetylglutamate; p-Hydroxyphenylacetylglutamic acid
Source Aromatic homomonocyclic compounds
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
61152160
HMDB ID
HMDB0006061
Formula
C13H15NO6
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C05595
FooDB ID
FDB023825
Physicochemical Properties Molecular Weight 281.26 Topological Polar Surface Area 124
XlogP 0.3 Complexity 362
Heavy Atom Count 20 Rotatable Bond Count 7
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 6
Function
Involved in tyrosine and phenylalanine metabolism.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Apolipoprotein (Apo)
            Apolipoprotein A-II (APOA2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (-265T >C(rs5082)) of APOA2
                      Induced Change 4-Hydroxyphenylacetylglutamic acid concentration: decrease (FC = 0.50)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Obesity [ICD-11: 5B81]
                      Details It is reported that mutation (-265T >C(rs5082)) of APOA2 leads to the decrease of 4-hydroxyphenylacetylglutamic acid levels compared with control group.
References
1 Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. Am J Clin Nutr. 2018 Jul 1;108(1):188-200.

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