Details of Metabolite

General Information of MET (ID: META00547)
Name Ceramide(d18:1/24:0)
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(2S,3R,4E)-2-Acylaminooctadec-4-ene-1,3-diol; (2S,3R,4E)-2-acylamino-1,3-Octadec-4-enediol; C24 Cer; C24-Ceramide; C24:0 Ceramide; Cer; Cer d18:1/24:0; Cer(d18:1/24:0); Ceramide; Ceramide (d18:1,C24:0); Ceramide (d18:1/24:0); Ceramide 24; Ceramide d18:1/24:0; Ceramide(d18:1/24:0); D-erythro-1,3-Dihydroxy-2-tetracosanoylamido-trans-4-octadecene; N-(Tetracosanoyl)-sphing-4-enine; N-(Tetracosanoyl)ceramide; N-(Tetracosanoyl)sphing-4-enine; N-Acylsphingosine; N-Lignoceroylsphingosine; N-Tetracosanoyl C18-sphingosine; N-Tetracosanoylsphing-4-enine; N-[(1S,2R,3E)-2-Hydroxy-1-(hydroxymethyl)-3-heptadecenyl]-octadecanamide
Source Endogenous;Sphingolipids;Food
Structure Type   Ceramides  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Sphingolipids
Ceramides
PubChem CID
5283571
HMDB ID
HMDB0004956
Formula
C42H83NO3
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00195
ChEBI ID
72965
FooDB ID
FDB023543
ChemSpider ID
4446684
METLIN ID
7209
Physicochemical Properties Molecular Weight 650.1 Topological Polar Surface Area 69.6
XlogP 17.2 Complexity 622
Heavy Atom Count 46 Rotatable Bond Count 38
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 3
Function
Ceramides (N-acylsphingosine) are one of the hydrolysis byproducts of sphingomyelin by the enzyme sphingomyelinase (sphingomyelin phosphorylcholine phosphohydrolase E.C.3.1.4.12) which has been identified in the subcellular fractions of human epidermis and many other tissues. They can also be synthesized from serine and palmitate in a de novo pathway and are regarded as important cellular signals for inducing apoptosis. Is key in the biosynthesis of glycosphingolipids and gangliosides.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Bone morphogenic antagonist (BMA)
            DAN domain family member 5 (DAND5) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (siRNA) of DAND5
                      Induced Change Ceramide(d18:1/24:0) concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockdown of DAND5 leads to the decrease of ceramide(d18:1/24:0) levels compared with control group.
References
1 Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P. FASEB J. 2006 Sep;20(11):1813-25.

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