Details of Metabolite

General Information of MET (ID: META00522)
Name 3'-AMP
Synonyms   Click to Show/Hide Synonyms of This Metabolite
3'-Adenosine monophosphate, 3'-Adenylic acid, Adenosine 3'-monophosphate, Adenosine 3'-phosphate, Adenosine-3'-monophosphate, AMP 3'-Phosphate, 'Synadenylic acid', 3'-Adenosine monophosphoric acid, 3'-Adenylate, Adenosine 3'-monophosphoric acid, Adenosine 3'-phosphoric acid, Adenosine-3'-monophosphoric acid, AMP 3'-Phosphoric acid, 'Synadenylate', Adenosine-3'-phosphate, 'Yeast adenylic acid', 2' Adenylic acid, 5' Adenylic acid, 'Phosphate dipotassium, adenosine', 5'-Adenylic acid, 'Adenylic acid', 5'-Phosphate, adenosine, Adenosine 2'-phosphate, 'Dipotassium, adenosine phosphate; Adenosine monophosphate; Adenosine phosphate disodium', 2' Adenosine monophosphate, Acid, 2'-adenylic, Acid, 5'-adenylic, Adenosine 5' phosphate, Adenosine 5'-phosphate; Phosphaden', 2'-Adenylic acid, 'AMP; Phosphate disodium, adenosine', monoPhosphate, 2'-adenosine, 2'-AMP, 2'-Adenosine monophosphate, Adenosine 2' phosphate, 'Adenosine phosphate dipotassium', Adenosine 3' phosphate, 'Disodium, adenosine phosphate
Source Endogenous;Escherichia Coli Metabolite;Food;Microbial
Structure Type   Ribonucleoside 3'-phosphates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Nucleosides, nucleotides, and analogues
Ribonucleoside 3'-phosphates
PubChem CID
41211
HMDB ID
HMDB0003540
Formula
C10H14N5O7P
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C01367
ChEBI ID
28931
FooDB ID
FDB023193
ChemSpider ID
37610
Physicochemical Properties Molecular Weight 347.22 Topological Polar Surface Area 186
XlogP -2.7 Complexity 481
Heavy Atom Count 23 Rotatable Bond Count 4
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 11
Function
Adenylic acid. Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. 3'-AMP has been identified in the human placenta.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Sulfatase sulf-1 (SULF1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (shRNA) of SULF1
                      Induced Change 3'-AMP concentration: decrease (FC = 0.81)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Ovarian cancer [ICD-11: 2C73]
                      Details It is reported that knockdown of SULF1 leads to the decrease of 3'-AMP levels compared with control group.
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Knockout of TP53
                      Induced Change 3'-AMP concentration: decrease (Log2 FC=0.58)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the decrease of 3'-AMP levels compared with control group.
References
1 Erratum to: Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab. 2014 Nov 4;2:24.
2 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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