Details of Metabolite

General Information of MET (ID: META00518)
Name D-Lysine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(R)-2,6-Diaminohexanoate; (R)-2,6-Diaminohexanoic acid; D-2,6-Diaminohexanoate; D-2,6-Diaminohexanoic acid; D-Lysin; DLY
Source Aliphatic acyclic compounds
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
57449
HMDB ID
HMDB0003405
Formula
C6H14N2O2
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00739
DrugBank ID
DB03252
ChEBI ID
16855
FooDB ID
FDB023163
Physicochemical Properties Molecular Weight 146.19 Topological Polar Surface Area 89.3
XlogP -3 Complexity 106
Heavy Atom Count 10 Rotatable Bond Count 5
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 4
Function
D-Lysine is an essential amino acid. It is often added to animal feed.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      GPCR secretin (GPCR-2)
            Glucagon receptor (GCGR) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Antagonist (GRA1) of GCGR
                      Induced Change D-Lysine concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Hyperglycemic hyperosmolar syndrome [ICD-11: 5A20]
                      Details It is reported that antagonist of GCGR leads to the increase of D-Lysine levels compared with control group.
References
1 Anti-diabetic efficacy and impact on amino acid metabolism of GRA1, a novel small-molecule glucagon receptor antagonist. PLoS One. 2012;7(11):e49572.

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