Details of Metabolite

General Information of MET (ID: META00514)
Name N2-Acetylornithine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(2S)-2-Acetamido-5-aminopentanoate; (2S)-2-Acetamido-5-aminopentanoic acid; (2S)-5-Amino-2-acetamidopentanoic acid; AOR; Acetyl-ornithine; N(2)-Acetyl-L-ornithine; N(alpha)-Acetyl-L-ornithine; N-Acetyl-L-ornithine; N-Acetylornithine; N2-Acetyl-L-ornithine; N2-Acetylornithine; Nalpha-Acetyl-L-ornithine
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;TCM Ingredients;Microbial
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
439232
HMDB ID
HMDB0003357
Formula
C7H14N2O3
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=439232"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00437
ChEBI ID
16543
FooDB ID
FDB031020
ChemSpider ID
388369
Physicochemical Properties Molecular Weight 174.2 Topological Polar Surface Area 92.4
XlogP -4.8 Complexity 170
Heavy Atom Count 12 Rotatable Bond Count 5
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 4
Function
N2-Acetylornithine, also known as N(alpha)-acetylornithine, belongs to the class of organic compounds known as N-acyl-L-alpha-amino acids. These are N-acylated alpha-amino acids which have the L-configuration of the alpha-carbon atom. N-Acetylornithine is a minor component of the deproteinized blood plasma of human blood. Human blood plasma contains a variable amount of acetylornithine, averaging 1.1 +/- 0.4 umol/L (range 0.8-0.2 umol/L). Urine contains a very small amount of acetylornithine, approximately 1 nmol/mg creatinine (1 umol/day).
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Sulfatase sulf-1 (SULF1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (shRNA) of SULF1
                      Induced Change N2-Acetylornithine concentration: decrease (FC = 0.51)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Ovarian cancer [ICD-11: 2C73]
                      Details It is reported that knockdown of SULF1 leads to the decrease of N2-acetylornithine levels compared with control group.
References
1 Erratum to: Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab. 2014 Nov 4;2:24.

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