Details of Metabolite

General Information of MET (ID: META00507)
Name Indole-3-carboxylic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
1H-Indole-3-carboxylate; 1H-Indole-3-carboxylic acid; 3-Carboxyindole; 3-Indole carboxylic acid; 3-Indolecarboxylate; 3-Indolecarboxylic acid; 3-Indoleformate; 3-Indoleformic acid; 3-Indolylcarboxylate; 3-Indolylcarboxylic acid; Indole - 3 carboxylate; Indole - 3 carboxylic acid; Indole-3-carboxylate; Indole-3-carboxylic acid; Indole-3-carboxylicacid
Source Food;Plant;Metabolite;Food;TCM Ingredients;Plant Metabolite
Structure Type   Indolecarboxylic acids and derivatives  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organoheterocyclic compounds
Indoles and derivatives
Indolecarboxylic acids and derivatives
PubChem CID
69867
HMDB ID
HMDB0003320
Formula
C9H7NO2
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C19837
ChEBI ID
24809
FooDB ID
FDB000935
ChemSpider ID
63063
METLIN ID
3795
Physicochemical Properties Molecular Weight 161.16 Topological Polar Surface Area 53.1
XlogP 2 Complexity 193
Heavy Atom Count 12 Rotatable Bond Count 1
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 2
Function
Indole-3-carboxylic acid is a normal urinary indolic tryptophan metabolite and has been found elevated in patients with liver diseases.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Leukotriene-C4 hydrolase (GGT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (siRNA) of GGT1
                      Induced Change Indole-3-carboxylic acid concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Renal cell carcinoma [ICD-11: 2C90]
                      Details It is reported that knockdown of GGT1 leads to the increase of indole-3-carboxylic acid levels compared with control group.
References
1 Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6274-E6282.

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